Recurring genomic breaks in independent lineages support genomic fragility.
Recurring genomic breaks in independent lineages support genomic fragility.
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DOI：
10.1186/1471-2148-6-90
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发表时间：
2006-11-07
影响因子：
3.4
通讯作者：
Hannenhalli, Sridhar
中科院分区：
文献类型：
--
作者：
Hinsch, Hanno;Hannenhalli, Sridhar
最近的发现表明，基因组中的进化断裂并不是随机分布的，某些区域，即所谓的脆弱区域，容易发生断裂。以前的方法来研究基因组的脆弱性，检查了分布的断裂，以及断裂与片段的重复和重复，在一个单一的物种。相反，我们调查这种区域脆弱性是否是一种固有的基因组特征，因此在多个独立的谱系中是保守的。我们通过量化某些基因组区域在独立谱系中重复破坏的程度来做到这一点。我们的调查，基于人类，黑猩猩，小鼠，大鼠，狗和鸡，表明染色体区域断裂的倾向是显着相关的独立谱系，即使考虑协变量。此外，脆弱区域是分段重复的富集区。基于一种新的方法，我们的工作为脆弱区域的存在提供了额外的支持。
Recent findings indicate that evolutionary breaks in the genome are not randomly distributed, and that certain regions, so-called fragile regions, are predisposed to breakages. Previous approaches to the study of genomic fragility have examined the distribution of breaks, as well as the coincidence of breaks with segmental duplications and repeats, within a single species. In contrast, we investigate whether this regional fragility is an inherent genomic characteristic and is thus conserved over multiple independent lineages. We do this by quantifying the extent to which certain genomic regions are disrupted repeatedly in independent lineages. Our investigation, based on Human, Chimp, Mouse, Rat, Dog and Chicken, suggests that the propensity of a chromosomal region to break is significantly correlated among independent lineages, even when covariates are considered. Furthermore, the fragile regions are enriched for segmental duplications. Based on a novel methodology, our work provides additional support for the existence of fragile regions.
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