Some biological properties of Pneumococcus type 37 and the chemistry of its capsular polysaccharide.
Some biological properties of Pneumococcus type 37 and the chemistry of its capsular polysaccharide.
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DOI：
10.1084/jem.132.3.475
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发表时间：
1970-09-01
影响因子：
15.3
通讯作者：
AUSTRIAN, R
中科院分区：
文献类型：
--
作者：
KNECHT, JC;SCHIFFMAN, G;AUSTRIAN, R
37型肺炎球菌与3型肺炎球菌一样，其特点是在固体培养基表面产生大的黏液菌落，其被膜非常大。它与高毒力的3型肺炎球菌的不同之处在于，它对小鼠和大鼠只有轻微的毒力，很少从人身上分离出来。本文描述了37型肺炎球菌在与3型肺炎球菌研究中使用的系统相当的系统中的行为研究以及37型肺炎球菌胶囊的化学结构检查。37型肺炎球菌的荚膜多糖是一种粘性的、光学活性的聚合物，由95%的己糖组成。葡萄糖经酸水解得率为88%。高碘酸盐氧化研究和多糖在酸水解中的行为表明，该分子由一个由1,3葡萄糖基-葡萄糖重复单元组成的核心组成，葡萄糖短链以频繁的间隔附着在其上。本文描述了一种性质与槐糖（β1→2葡萄糖-葡萄糖）相同的二糖和一种三糖的分离。提出了37型肺炎球菌荚膜多糖的初步结构。
Pneumococcus Type 37, like pneumococcus Type 3, is characterized by the production of large mucoid colonies on the surface of solid media and by its very large capsule. It differs from the highly virulent pneumococcus Type 3 in that it is only slightly virulent for mice and rats and is isolated infrequently from man. A study of the behavior of pneumococcus Type 37 in systems comparable to those used in the study of pneumococcus Type 3 and an examination of the chemical structure of the capsule of pneumococcus Type 37 are described. The capsular polysaccharide of pneumococcus Type 37 is a viscous, optically inactive polymer composed of 95% hexose. Glucose is obtained in 88% yield upon acid hydrolysis. Periodate oxidation studies and the behavior of the polysaccharide on acid hydrolysis suggest that the molecule consists of a core of repeating units of 1,3 glucosyl-glucose to which short chains of glucose are attached at frequent intervals. Isolation of a disaccharide, the properties of which are identical with those of sophorose (β1 → 2 glucosyl-glucose), and of a trisaccharide are described. A tentative structure for the capsular polysaccharide of pneumococcus Type 37 is proposed.
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影响因子：
15
作者：
SCHIFFMAN, G;KABAT, EA;LESKOWITZ, S
通讯作者：
LESKOWITZ, S
DOI：
10.1084/jem.92.1.85
发表时间：
1950-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
WOOD WB;SMITH MR
通讯作者：
SMITH MR
影响因子：
15.3
作者：
BORNSTEIN, DL;SCHIFFMAN, G;AUSTRIAN, R
通讯作者：
AUSTRIAN, R
影响因子：
4.1
作者：
FAIRBRIDGE, RA;WILLIS, KJ;BOOTH, RG
通讯作者：
BOOTH, RG
DOI：
10.1084/jem.84.4.387
发表时间：
1946-09-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Wood WB;Smith MR;Watson B
通讯作者：
Watson B