Elevated Th17 cell frequencies and Th17/Treg ratio are associated with airway hyperresponsiveness in asthmatic children
Elevated Th17 cell frequencies and Th17/Treg ratio are associated with airway hyperresponsiveness in asthmatic children
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Th17 细胞频率和 Th17/Treg 比率升高与哮喘儿童气道高反应性相关
DOI：
10.1080/02770903.2020.1737710
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发表时间：
2020-03
影响因子：
1.9
通讯作者：
Weixi Zhang
中科院分区：
文献类型：
--
作者：
Rongying Zheng;Fangmin Wang;Yue Huang;Qiangwei Xiang;Huan Dai;Weixi Zhang
Abstract Introduction: The elevation of T helper (Th)17 cell frequencies and the imbalance of Th17/regulatory T (Treg) cells occur in asthma pathogenesis. Airway hyperresponsiveness (AHR) is a cardinal feature of asthma, and Th17 responses can promote AHR. We hypothesized that changes in Th17 cells and the Th17/Treg ratio correlate with AHR in asthmatic children. Methods: Twenty asthmatic children and twenty healthy children were included in the study. The peak expiratory flow (PEF) % pred, forced expiratory volume in 1 s (FEV1) % pred and the FEV1/forced vital capacity (FVC) ratio were measured in all subjects. Methacholine challenge test (MCT) was performed in asthmatic children. Flow cytometric analysis was used to determine the proportions of Th17 and Treg cells in peripheral blood mononuclear cells. ELISA was used to assess serum levels of interleukin (IL)-17A and IL-10. Results: Th17 cell frequencies (2.272 ± 0.207% in asthmatics, 1.193 ± 0.131% in controls, P < 0.01) and Th17/Treg ratios (0.371 ± 0.0387 in asthmatics, 0.183 ± 0.020 in controls, P < 0.01) were significantly increased in asthmatic children compared to controls. In asthmatic children, the MCT grade had positive correlations with the Th17 cell frequencies [r = 0.718, P < 0.01], serum IL-17A level [r = 0.753, P < 0.01] and Th17/Treg ratio [r = 0.721, P < 0.01], while the log10PD20-FEV1 value was negatively correlated with the Th17 cell frequencies [r = −0.654, P < 0.01], serum IL-17A level [r = −0.652, P < 0.01] and Th17/Treg ratio [r = −0.625, P < 0.01]. Conclusion: Th17 cell, IL-17A and Th17/Treg ratio were positively correlated with AHR in asthmatic children. It may be helpful to monitor Th17 cells and the Th17/Treg ratio as indicators of AHR in clinical practice.
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影响因子：
3.3
作者：
Imani, Saber;Salimian, Jafar;Panahi, Yunes
通讯作者：
Panahi, Yunes
影响因子：
1.9
作者：
Furukawa, Toshiki;Sakagami, Takuro;Narita, Ichiei
通讯作者：
Narita, Ichiei
雷公藤红素可减轻肥胖哮喘小鼠的气道高反应性并抑制 Th17 反应
影响因子：
5.6
作者：
Zeng Z;Lin X;Zheng R;Zhang H;Zhang W
通讯作者：
Zhang W
DOI：
10.1186/1476-7961-11-1
发表时间：
2013-01-25
期刊：
Clinical and molecular allergy : CMA
影响因子：
--
作者：
Singh AM;Dahlberg P;Burmeister K;Evans MD;Gangnon R;Roberg KA;Tisler C;Dasilva D;Pappas T;Salazar L;Lemanske RF Jr;Gern JE;Seroogy CM
通讯作者：
Seroogy CM
影响因子：
--
作者：
A. Ray;L. Cohn
通讯作者：
A. Ray;L. Cohn