Translaminar recurrence from layer 5 suppresses superficial cortical layers.
Translaminar recurrence from layer 5 suppresses superficial cortical layers.
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DOI：
10.1038/s41467-022-30349-w
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发表时间：
2022-05-11
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
感觉皮层中的信息流被描述为一个主要的前馈序列，深层作为输出结构。虽然经常性的兴奋性预测从层5（L5）到浅表L2/3已被确定的解剖和生理研究，其功能的影响感觉处理仍然不清楚。在这里，我们在初级听觉皮层中使用层选择性光遗传学操作来证明，无论唤醒水平如何，来自L5的反馈输入都会抑制浅层的活动，这与其兴奋性连接的预测相反。这种抑制作用主要是通过端脑内神经元介导的translaminar电路，与锥体束神经元的皮质下投射的额外贡献。此外，L5激活锐化频域和时域的浅层的音调诱发反应，表明其对皮层的频谱-时间整合的影响。总之，我们的研究结果建立了一个translaminar抑制复发从深层锐化功能选择性表层皮质层。在感觉加工中，第5层和第2/3层之间的经椎板反馈投射的作用仍不清楚。在这里，作者表明，来自第5层的上行投射抑制了浅表层，并且这种跨层反馈增强了初级听觉皮层的特征选择性。
Information flow in the sensory cortex has been described as a predominantly feedforward sequence with deep layers as the output structure. Although recurrent excitatory projections from layer 5 (L5) to superficial L2/3 have been identified by anatomical and physiological studies, their functional impact on sensory processing remains unclear. Here, we use layer-selective optogenetic manipulations in the primary auditory cortex to demonstrate that feedback inputs from L5 suppress the activity of superficial layers regardless of the arousal level, contrary to the prediction from their excitatory connectivity. This suppressive effect is predominantly mediated by translaminar circuitry through intratelencephalic neurons, with an additional contribution of subcortical projections by pyramidal tract neurons. Furthermore, L5 activation sharpened tone-evoked responses of superficial layers in both frequency and time domains, indicating its impact on cortical spectro-temporal integration. Together, our findings establish a translaminar inhibitory recurrence from deep layers that sharpens feature selectivity in superficial cortical layers. The role of translaminar feedback projections between layer 5 and layers 2/3 in sensory processing remains unclear. Here, the authors show that ascending projections from layer 5 suppress superficial layers, and that this translaminar feedback sharpens feature selectivity in the primary auditory cortex.
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影响因子：
2.5
作者：
Hattox, Alexis M.;Nelson, Sacha B.
通讯作者：
Nelson, Sacha B.
影响因子：
16.2
作者：
Atallah BV;Bruns W;Carandini M;Scanziani M
通讯作者：
Scanziani M
影响因子：
25
作者：
Dantzker, JL;Callaway, EM
通讯作者：
Callaway, EM
影响因子：
16.2
作者：
Kim EJ;Juavinett AL;Kyubwa EM;Jacobs MW;Callaway EM
通讯作者：
Callaway EM
DOI：
10.1126/science.aac9462
发表时间：
2015-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang X;Shen S;Cadwell CR;Berens P;Sinz F;Ecker AS;Patel S;Tolias AS
通讯作者：
Tolias AS