Neurobiology of stress-induced reproductive dysfunction in female macaques.
Neurobiology of stress-induced reproductive dysfunction in female macaques.
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DOI：
10.1007/s12035-008-8042-z
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发表时间：
2008-12
影响因子：
5.1
通讯作者：
Cameron JL
中科院分区：
文献类型：
--
作者：
Bethea CL;Centeno ML;Cameron JL
现在人们普遍认为压力会导致精神和身体疾病。然而，越来越清楚的是，在同样的压力下，有些人非常脆弱，会屈服于疾病，而另一些人则更有弹性，更有效地应对，而不是生病。个体之间的这种差异被称为压力敏感性。一个人的压力敏感性似乎受到遗传因素、早期生活（甚至产前）压力以及提供压力保护的因素的存在或缺乏的影响。与其他与压力相关的疾病相比，对压力诱导的生殖功能障碍的敏感性与恢复力的概念相对较少受到关注。本文提出的研究是为了开始确定对应激性生殖功能障碍敏感的个体的稳定特征和神经基础。月经周期正常的雌性食蟹猕猴在暴露于代谢和社会心理双重压力下，要么停止排卵（应激敏感），要么继续排卵（应激弹性）。然而，即使在没有应激的情况下，应激敏感动物卵巢类固醇激素、雌激素和黄体酮的分泌减少，心率加快，血清素功能降低，血清素神经元减少，血清素相关关键基因表达降低，下丘脑5HT2A和2C基因表达降低，下丘脑GAD67和CRH基因表达升高，GnRH转运至垂体前叶减少。总之，研究结果表明，应激敏感个体的生殖回路的神经生物学受到了损害。我们推测，随着压力的施加，这些神经系统的功能失调加剧，生殖功能停止。
It is now well accepted that stress can precipitate mental and physical illness. However, it is becoming clear that given the same stress, some individuals are very vulnerable and will succumb to illness while others are more resilient and cope effectively, rather than becoming ill. This difference between individuals is called stress sensitivity. Stress-sensitivity of an individual appears to be influenced by genetically inherited factors, early life (even prenatal) stress, and by the presence or absence of factors that provide protection from stress. In comparison to other stress-related diseases, the concept of sensitivity versus resilience to stress-induced reproductive dysfunction has received relatively little attention. The studies presented herein were undertaken to begin to identify stable characteristics and the neural underpinnings of individuals with sensitivity to stress-induced reproductive dysfunction. Female cynomolgus macaques with normal menstrual cycles either stop ovulating (Stress Sensitive) or to continue to ovulate (Stress Resilient) upon exposure to a combined metabolic and psychosocial stress. However, even in the absence of stress, the stress sensitive animals have lower secretion of the ovarian steroids, estrogen and progesterone, have higher heart rates, have lower serotonin function, have fewer serotonin neurons and lower expression of pivotal serotonin-related genes, have lower expression of 5HT2A and 2C genes in the hypothalamus, have higher gene expression of GAD67 and CRH in the hypothalamus and have reduced GnRH transport to the anterior pituitary. Altogether, the results suggest that the neurobiology of reproductive circuits in stress sensitive individuals is compromised. We speculate that with the application of stress, the dysfunction of these neural systems becomes exacerbated and reproductive function ceases.
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影响因子：
1.7
作者：
AIELLOZALDIVAR, M;LUINE, V;FRANKFURT, M
通讯作者：
FRANKFURT, M
DOI：
10.1111/j.1530-0277.2001.tb02269.x
发表时间：
2001-05-01
影响因子：
3.2
作者：
Anthenelli, RM;Maxwell, RA;Hauger, R
通讯作者：
Hauger, R
影响因子：
9.8
作者：
BARBARINO, A;DEMARINIS, L;BARINI, A
通讯作者：
BARINI, A
影响因子：
5.8
作者：
BILLER, BMK;FEDEROFF, HJ;KLIBANSKI, A
通讯作者：
KLIBANSKI, A
影响因子：
4.8
作者：
BAGDY, G;MAKARA, GB
通讯作者：
MAKARA, GB