Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma.
Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma.
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DOI：
10.1002/jnr.21699
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发表时间：
2008-08-15
影响因子：
4.2
通讯作者：
Brozoski, Thomas J.
中科院分区：
文献类型：
--
作者：
Bauer, Carol A.;Turner, Jeremy G.;Caspary, Donald M.;Myers, Kristin S.;Brozoski, Thomas J.
关键词：
长期以来的假设是，耳鸣，即在没有外部声源的情况下对声音的感知，是由耳蜗毛细胞(HC)损伤的独特模式引发的，这随后导致中枢听觉通路中神经活动的改变。通过评估单侧耳蜗伤后耳鸣和下丘(IC)自发神经活动的行为证据，验证了这一假设。将栗鼠分成4个人工耳蜗组。每种处理都会产生一种不同的HC损伤模式。声暴露(AEX)：稀疏低频内毛细胞(IHC)和外毛细胞(OHC)丢失；圆窗顺铂(CisEx)：显著OHC丢失混合部分IHC丢失；圆窗卡铂(CarbEx)：显著IHC丢失而不丢失OHC；对照：无丢失。与对照组相比，所有实验组都表现出显著和相似的耳鸣心理物理证据，其特征类似于1千赫的音调。AEX组和CisEx组对侧IC自发活动增强，表现为棘波增强和跨纤维同步性增强。一项多维分析发现，在患有耳鸣的动物中，神经元的亚群更为普遍。这些单位的特点是高突发，低ISI方差，以及突发内峰值尖峰约为1000/秒。结果表明，耳蜗术后，耳鸣患者的中枢活动会发生多种改变，而耳蜗术后的损伤并不是耳鸣的具体表现。特别受影响的是IC神经元的亚群，具有所描述的独特的三联体特征。
A long-standing hypothesis is that tinnitus, the perception of sound without an external acoustic source, is triggered by a distinctive pattern of cochlear hair cell (HC) damage and this subsequently leads to altered neural activity in the central auditory pathway. This hypothesis was tested by assessing behavioral evidence of tinnitus and spontaneous neural activity in the inferior colliculus (IC) after unilateral cochlear trauma. Chinchillas were assigned to 4 cochlear treatment groups. Each treatment produced a distinctive pattern of HC damage. Acoustic exposure (AEx): sparse low-frequency inner hair cell (IHC) and outer hair cell (OHC) loss; round window cisplatin (CisEx): pronounced OHC loss mixed with some IHC loss; round window carboplatin (CarbEx): pronounced IHC loss without OHC loss; control: no loss. Compared to controls, all experimental groups displayed significant and similar psychophysical evidence of tinnitus with features resembling a 1 kHz tone. Contralateral IC spontaneous activity was elevated in the AEx and CisEx groups, which showed increased spiking and increased cross-fiber synchrony. A multi-dimensional analysis identified a subpopulation of neurons more prevalent in animals with tinnitus. These units were characterized by high bursting, low ISI variance, and within-burst peak spiking of approximately 1000/sec. It was concluded that cochlear trauma in general, rather than its specific features, leads to multiple changes in central activity that underpin tinnitus. Particularly affected was a subpopulation ensemble of IC neurons with the described unique triad of features.
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DOI：
10.1007/s101620010030
发表时间：
2001-03-01
影响因子：
2.4
作者：
Bauer, CA;Brozoski, TJ
通讯作者：
Brozoski, TJ
影响因子：
2.4
作者：
LOEB, M;SMITH, RP
通讯作者：
SMITH, RP
影响因子：
1.7
作者：
Alkhatib, Ala;Biebel, Ulrich W.;Smolders, Jean W. T.
通讯作者：
Smolders, Jean W. T.
影响因子：
3
作者：
Brozoski, TJ;Caspary, DM;Bauer, CA
通讯作者：
Bauer, CA
影响因子：
2.8
作者：
Kaltenbach, JA;Afman, CE
通讯作者：
Afman, CE