Age-related changes in basal forebrain afferent activation in response to food paired stimuli.
Age-related changes in basal forebrain afferent activation in response to food paired stimuli.
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DOI：
10.1016/j.neulet.2023.137155
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发表时间：
2023-04-01
影响因子：
2.5
通讯作者：
Fadel, Jim R.
中科院分区：
文献类型：
--
作者：
Somera, Brandy;Frick, Marla;Fadel, Jim R.
基底前脑包含一个表型多样的神经元集合，包括那些使用乙酰胆碱作为神经递质的神经元。这个基底前脑胆碱能系统投射到整个新皮层地幔以及包括海马和杏仁核在内的皮层下边缘结构。基底前脑病理学，包括胆碱能功能障碍，被认为是与几种年龄相关的神经退行性疾病，包括阿尔茨海默病相关的认知障碍的基础。基底前脑功能障碍可能部分源于该区域胆碱能神经元和其他神经元的正常传入调节失败。然而，很少有人了解如何老化，单独，影响基底前脑传入的动机行为的背景下的功能调节。在这里，我们使用神经束跟踪结合动机显着刺激在老年啮齿动物模型，研究如何老化改变活动的基底前脑输入所产生的几个皮层，边缘系统和脑干结构。与老年大鼠相比，年轻大鼠表现出更大的刺激相关激活基底前脑输入产生的边缘前皮层，核腹侧被盖区。与年轻动物相比，老年大鼠对可口食物的反应延迟也有所增加。还观察到内在基底前脑细胞群或传入神经激活的变化作为年龄或实验条件的函数。这些数据进一步表明，基底前脑激活和相关的行为和认知功能的年龄相关的变化反映了这个重要的大脑区域的传入调节失败。
The basal forebrain contains a phenotypically-diverse assembly of neurons, including those using acetylcholine as their neurotransmitter. This basal forebrain cholinergic system projects to the entire neocortical mantle as well as subcortical limbic structures that include the hippocampus and amygdala. Basal forebrain pathology, including cholinergic dysfunction, is thought to underlie the cognitive impairments associated with several age-related neurodegenerative conditions, including Alzheimer’s disease. Basal forebrain dysfunction may stem, in part, from a failure of normal afferent regulation of cholinergic and other neurons in this area. However, little is understood regarding how aging, alone, affects the functional regulation of basal forebrain afferents in the context of motivated behavior. Here, we used neuronal tract-tracing combined with motivationally salient stimuli in an aged rodent model to examine how aging alters activity in basal forebrain inputs arising from several cortical, limbic and brainstem structures. Young rats showed greater stimulus-associated activation of basal forebrain inputs arising from prelimbic cortex, nucleus accumbens and the ventral tegmental area compared with aged rats. Aged rats also showed increased latency to respond to palatable food presentation compared to young animals. Changes in activation of intrinsic basal forebrain cell populations or afferents were also observed as a function of age or experimental condition. These data further demonstrate that age-related changes in basal forebrain activation and related behavioral and cognitive functions reflect a failure of afferent regulation of this important brain region.
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影响因子：
2.5
作者：
Griffith, William H.;DuBois, Dustin W.;Murchison, David
通讯作者：
Murchison, David
与年龄相关的基础前脑胆碱能和GABA能投射神经元的变化：与空间障碍的关系。
影响因子：
4.2
作者：
Bañuelos C;LaSarge CL;McQuail JA;Hartman JJ;Gilbert RJ;Ormerod BK;Bizon JL
通讯作者：
Bizon JL
影响因子：
3.1
作者：
McKenna JT;Yang C;Bellio T;Anderson-Chernishof MB;Gamble MC;Hulverson A;McCoy JG;Winston S;Hodges E;Katsuki F;McNally JM;Basheer R;Brown RE
通讯作者：
Brown RE
影响因子：
2.9
作者：
Gaykema, RPA;Zaborszky, L
通讯作者：
Zaborszky, L
影响因子：
8.8
作者：
Lozano-Montes, Laura;Dimanico, Marta;Rainer, Gregor
通讯作者：
Rainer, Gregor