Cerebellar theta burst stimulation modulates the neural activity of interconnected parietal and motor areas.
Cerebellar theta burst stimulation modulates the neural activity of interconnected parietal and motor areas.
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DOI：
10.1038/srep36191
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发表时间：
2016-10-31
影响因子：
4.6
通讯作者：
Koch G
中科院分区：
文献类型：
--
作者：
Casula EP;Pellicciari MC;Ponzo V;Stampanoni Bassi M;Veniero D;Caltagirone C;Koch G
自主运动控制和执行是通过齿状丘脑连接，通过不同互连皮质区域的小脑输出的影响来调节的。在本研究中，我们应用经颅磁刺激（TMS）和脑电图（EEG）来直接评估小脑θ突发刺激（TBS）对一组健康志愿者的控制侧初级运动皮层（M1）和后顶叶皮层（PPC）的影响。我们发现对 TMS 诱发的活动存在依赖于 TBS 的双向调节；具体而言，TMS 后 100 至 200 毫秒之间，cTBS 活性增加，而 iTBS 活性降低，M1 和 PPC 区域的情况类似。在振荡域上，TBS 引起 M1 振荡固有频率的特定变化：cTBS 降低了 TMS 诱发的 α 活性，而 iTBS 增强了 β 活性。假刺激后未观察到任何影响。我们的数据提供了新的证据，表明小脑可能通过影响依赖于 GABA 能活动的特定中间神经元组来对皮层进行控制。我们发现，小脑 TBS 通过共同的时域、空间域和频域发挥作用，调节远处相互关联的皮质区域的皮质兴奋性。
Voluntary movement control and execution are regulated by the influence of the cerebellar output over different interconnected cortical areas, through dentato-thalamo connections. In the present study we applied transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to directly assess the effects of cerebellar theta-burst stimulation (TBS) over the controlateral primary motor cortex (M1) and posterior parietal cortex (PPC) in a group of healthy volunteers. We found a TBS-dependent bidirectional modulation over TMS-evoked activity; specifically, cTBS increased whereas iTBS decreased activity between 100 and 200 ms after TMS, in a similar manner over both M1 and PPC areas. On the oscillatory domain, TBS induced specific changes over M1 natural frequencies of oscillation: TMS-evoked alpha activity was decreased by cTBS whereas beta activity was enhanced by iTBS. No effects were observed after sham stimulation. Our data provide novel evidence showing that the cerebellum exerts its control on the cortex likely by impinging on specific set of interneurons dependent on GABA-ergic activity. We show that cerebellar TBS modulates cortical excitability of distant interconnected cortical areas by acting through common temporal, spatial and frequency domains.
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DOI：
10.1523/jneurosci.2184-09.2009
发表时间：
2009-07-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Galea JM;Jayaram G;Ajagbe L;Celnik P
通讯作者：
Celnik P
联合TMS和EEG的方法。
影响因子：
2.7
作者：
Ilmoniemi, Risto J.;Kicic, Dubravko
通讯作者：
Kicic, Dubravko
影响因子：
3.5
作者：
Baumann, Oliver;Borra, Ronald J.;Bower, James M.;Cullen, Kathleen E.;Habas, Christophe;Ivry, Richard B.;Leggio, Maria;Mattingley, Jason B.;Molinari, Marco;Moulton, Eric A.;Paulin, Michael G.;Pavlova, Marina A.;Schmahmann, Jeremy D.;Sokolov, Arseny A.
通讯作者：
Sokolov, Arseny A.
影响因子：
4.1
作者：
Casula, Elias Paolo;Bassi, Mario Stampanoni;Koch, Giacomo
通讯作者：
Koch, Giacomo
影响因子：
2.5
作者：
Fernandez Del Olmo, Miguel;Cheeran, Binith;Rothwell, John C.
通讯作者：
Rothwell, John C.