Origin and evolution of HIV-1 subtype A6.
Origin and evolution of HIV-1 subtype A6.
复制标题
DOI：
10.1371/journal.pone.0260604
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Ali S
中科院分区：
文献类型：
--
作者：
Abidi SH;Aibekova L;Davlidova S;Amangeldiyeva A;Foley B;Ali S
前苏联（FSU）国家的艾滋病毒爆发的特点是反复传播艾滋病毒变异AFSU，现在被归类为一个独特的亚型A亚型，称为A6。本研究使用系统发育/进化动力学和特征突变分析来确定A6亚型与其他A亚型之间可能的进化关系。对于本研究，使用来自A亚型的A1、A2、A3、A4、A5和A6亚型的总共553个全长、公开可用的逆转录酶序列进行初始最大似然系统发育分析。对于系统发生聚类和特征突变分析，分别使用总共5961和3959个pol和env序列。系统发育和特征突变分析表明，HIV-1 A6亚型可能起源于非洲起源的A1亚型。A6和A1 pol和env基因共有几个标志性突变，表明两种亚型之间的遗传相似性。对于A6，tMRCA的日期为1975年，比A1晚15年。目前的研究提供了深入了解的演变和多样化的A6在前苏联国家的背景下，并表明，前苏联国家的A6从A1的非洲起源演变，并得到前苏联地区以外的桥梁。
HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used phylogenetic/phylodynamic and signature mutation analyses to determine likely evolutionary relationship between subtype A6 and other subtype A sub-subtypes. For this study, an initial Maximum Likelihood phylogenetic analysis was performed using a total of 553 full-length, publicly available, reverse transcriptase sequences, from A1, A2, A3, A4, A5, and A6 sub-subtypes of subtype A. For phylogenetic clustering and signature mutation analysis, a total of 5961 and 3959 pol and env sequences, respectively, were used. Phylogenetic and signature mutation analysis showed that HIV-1 sub-subtype A6 likely originated from sub-subtype A1 of African origin. A6 and A1 pol and env genes shared several signature mutations that indicate genetic similarity between the two subtypes. For A6, tMRCA dated to 1975, 15 years later than that of A1. The current study provides insights into the evolution and diversification of A6 in the backdrop of FSU countries and indicates that A6 in FSU countries evolved from A1 of African origin and is getting bridged outside the FSU region.
登录
查看更多内容
影响因子：
3.7
作者：
Abidi, Syed Hani;Kalish, Marcia L.;Ali, Syed
通讯作者：
Ali, Syed
影响因子：
3.2
作者：
Diez-Fuertes, Francisco;Cabello, Marina;Thomson, Michael M.
通讯作者：
Thomson, Michael M.
影响因子：
3.7
作者：
Aibekova, Lazzat;Foley, Brian;Ali, Syed
通讯作者：
Ali, Syed
影响因子：
1.5
作者：
Neogi, Ujjwal;Gupta, Soham;Prasad, Vinayaka R.
通讯作者：
Prasad, Vinayaka R.
影响因子：
1.5
作者：
Reinis, M;Brucková, M;Carr, JK
通讯作者：
Carr, JK