Evolutionary determinants of genetic variation in susceptibility to infectious diseases in humans.
Evolutionary determinants of genetic variation in susceptibility to infectious diseases in humans.
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DOI：
10.1371/journal.pone.0029089
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Antonovics J
中科院分区：
文献类型：
--
作者：
Baker C;Antonovics J
虽然人类对传染病易感性的遗传变异长期以来一直受到重视，但很少有人把重点放在确定对不同疾病易感性变异水平的模式上。通过对基于家系的定量变异以及对不同类别的标记等位基因的研究进行调查，评估了与40种人类传染病相关的易感性遗传变异水平。这些估计值与病原体特征、流行病学特征和人类免疫反应的有效性相关。易感性遗传变异水平的最强预测因子是与免疫效果负相关的疾病特征。高水平的遗传变异与传染期长的疾病有关，而研制疫苗的努力一直没有成功。这些发现与基于理论模型的预测相一致，该模型结合了与不同类型阻力机制相关的健身成本。鉴于疾病易感性的遗传变异对疫苗开发和流行病学具有重大影响，对这些观察到的模式的了解将是指导未来研究的宝贵工具。
Although genetic variation among humans in their susceptibility to infectious diseases has long been appreciated, little focus has been devoted to identifying patterns in levels of variation in susceptibility to different diseases. Levels of genetic variation in susceptibility associated with 40 human infectious diseases were assessed by a survey of studies on both pedigree-based quantitative variation, as well as studies on different classes of marker alleles. These estimates were correlated with pathogen traits, epidemiological characteristics, and effectiveness of the human immune response. The strongest predictors of levels of genetic variation in susceptibility were disease characteristics negatively associated with immune effectiveness. High levels of genetic variation were associated with diseases with long infectious periods and for which vaccine development attempts have been unsuccessful. These findings are consistent with predictions based on theoretical models incorporating fitness costs associated with the different types of resistance mechanisms. An appreciation of these observed patterns will be a valuable tool in directing future research given that genetic variation in disease susceptibility has large implications for vaccine development and epidemiology.
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影响因子：
56.3
作者：
Burgner, David;Jamieson, Sarra E.;Blackwell, Jenefer M.
通讯作者：
Blackwell, Jenefer M.
DOI：
10.1101/sqb.1964.029.01.018
发表时间：
1964-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
ALLISON, AC
通讯作者：
ALLISON, AC
DOI：
10.1098/rspb.1994.0122
发表时间：
1994-09-22
影响因子：
4.7
作者：
BOWERS, RG;BOOTS, M;BEGON, M
通讯作者：
BEGON, M
DOI：
10.1046/j.1525-1381.1999.99235.x
发表时间：
1999-07-01
期刊：
PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS
影响因子：
--
作者：
Clegg, JB;Weatherall, DJ
通讯作者：
Weatherall, DJ
影响因子：
2.9
作者：
Boots, M;Haraguchi, Y
通讯作者：
Haraguchi, Y