The oral-gut axis: a missing piece in the IBD puzzle.
The oral-gut axis: a missing piece in the IBD puzzle.
复制标题
DOI：
10.1186/s41232-023-00304-3
复制
发表时间：
2023-11-06
影响因子：
8.1
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症性肠病（IBD）是一种多因素的难治性肠道疾病。仅关注IBD发病机制的一个方面不足以完全捕获疾病的复杂性，并导致临床管理的进展有限。因此，它是至关重要的解剖之间的相互作用的发病机制的各种贡献者，以全面了解其病理，并随后改善临床结果。在这种情况下，器官之间的系统性相互作用，特别是由宿主免疫细胞和常驻微生物介导的口-肠轴，在IBD研究中引起了极大的关注。更具体地说，牙周病，如牙周炎，已经涉及到扩大肠道炎症超出口腔的范围。越来越多的证据表明，潜在有害的口腔常驻细菌（称为致病菌）和来自口腔粘膜的促炎免疫细胞可以迁移到胃肠道，从而增强肠道炎症。本文旨在提供牙周病和肠道炎症之间的因果关系的整体概述。此外，我们将讨论促进口腔致病菌易位到肠道的潜在决定因素，这是支撑口腔-肠道轴的关键事件。揭开口腔-肠道连续体中微生物群和免疫力的复杂动力学将有助于更好地理解口腔和肠道疾病固有的病理生理学，并制定前瞻性治疗策略。
Inflammatory bowel disease (IBD) is a multifactorial intractable intestinal disease. Focusing on only one facet of the pathogenesis of IBD is insufficient to fully capture the complexity of the disease, and results in limited advance in clinical management. Therefore, it is critical to dissect the interactions amongst the multifarious contributors to the pathogenesis to comprehensively understand its pathology and subsequently improve clinical outcomes. In this context, the systemic interactions between organs, particularly the oral-gut axis mediated by host immune cells and resident microorganisms, have garnered significant attention in IBD research. More specifically, periodontal disease such as periodontitis has been implicated in augmenting intestinal inflammation beyond the confines of the oral cavity. There is mounting evidence suggesting that potentially harmful oral resident bacteria, termed pathobionts, and pro-inflammatory immune cells from the oral mucosa can migrate to the gastrointestinal tract, thereby potentiating intestinal inflammation. This article aims to provide a holistic overview of the causal relationship between periodontal disease and intestinal inflammation. Furthermore, we will discuss potential determinants that facilitate the translocation of oral pathobionts into the gut, a key event underpinning the oral-gut axis. Unraveling the complex dynamics of microbiota and immunity in the oral-gut continuum will lead to a better understanding of the pathophysiology inherent in both oral and intestinal diseases and the development of prospective therapeutic strategies.
登录
查看更多内容
DOI：
10.1126/science.aan4526
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Suda W;Luo C;Kawaguchi T;Motoo I;Narushima S;Kiguchi Y;Yasuma K;Watanabe E;Tanoue T;Thaiss CA;Sato M;Toyooka K;Said HS;Yamagami H;Rice SA;Gevers D;Johnson RC;Segre JA;Chen K;Kolls JK;Elinav E;Morita H;Xavier RJ;Hattori M;Honda K
通讯作者：
Honda K
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.1007/s00018-017-2693-8
发表时间：
2018-01
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Hugenholtz F;de Vos WM
通讯作者：
de Vos WM
影响因子：
5.7
作者：
Khan I;Bai Y;Zha L;Ullah N;Ullah H;Shah SRH;Sun H;Zhang C
通讯作者：
Zhang C
影响因子：
--
作者：
Chinnasamy, Alagesan;Ramalingam, Karthikeyan;Chawla, Gurveen
通讯作者：
Chawla, Gurveen