Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection.
Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection.
复制标题
肠道菌群定植抵抗与肠道病原菌感染的机制。
DOI：
10.3389/fcimb.2021.716299
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发表时间：
2021
影响因子：
5.7
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Khan I;Bai Y;Zha L;Ullah N;Ullah H;Shah SRH;Sun H;Zhang C
哺乳动物肠道微生物群落，被称为肠道微生物群，由数万亿细菌组成，它们与宿主共同进化，在多种宿主功能中发挥重要作用，包括营养获取、代谢和免疫发育，更重要的是，它在保护宿主免受与外源性病原体或可能由以下原因引起的内源性致病生物生长相关的肠道感染中起关键作用：健康肠道微生物群落破坏。微生物群通过复杂的机制来抑制病原菌的生长，包括营养竞争、竞争性代谢相互作用、生态位排斥和诱导宿主免疫反应等，统称为定殖抗性。另一方面，病原体也开发了对抗策略来扩大其种群并增强其毒力，以科普肠道微生物群定殖抗性并引起感染。本文综述了肠道菌群和肠道病原体之间复杂关系的现有文献，描述了肠道菌群如何介导对细菌肠道感染的定植抗性，以及细菌肠道病原体如何克服这种抗性，以及如何理解这种复杂的相互作用可以为未来的感染性疾病治疗提供信息。
The mammalian gut microbial community, known as the gut microbiota, comprises trillions of bacteria, which co-evolved with the host and has an important role in a variety of host functions that include nutrient acquisition, metabolism, and immunity development, and more importantly, it plays a critical role in the protection of the host from enteric infections associated with exogenous pathogens or indigenous pathobiont outgrowth that may result from healthy gut microbial community disruption. Microbiota evolves complex mechanisms to restrain pathogen growth, which included nutrient competition, competitive metabolic interactions, niche exclusion, and induction of host immune response, which are collectively termed colonization resistance. On the other hand, pathogens have also developed counterstrategies to expand their population and enhance their virulence to cope with the gut microbiota colonization resistance and cause infection. This review summarizes the available literature on the complex relationship occurring between the intestinal microbiota and enteric pathogens, describing how the gut microbiota can mediate colonization resistance against bacterial enteric infections and how bacterial enteropathogens can overcome this resistance as well as how the understanding of this complex interaction can inform future therapies against infectious diseases.
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影响因子：
64.8
作者：
Brandl, Katharina;Plitas, George;Mihu, Coralia N.;Ubeda, Carles;Jia, Ting;Fleisher, Martin;Schnabl, Bernd;DeMatteo, Ronald P.;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.1424409112
发表时间：
2015-04-28
影响因子：
11.1
作者：
Bouslimani, Amina;Porto, Carla;Dorrestein, Pieter C.
通讯作者：
Dorrestein, Pieter C.
影响因子：
56.9
作者：
Bry, L;Falk, PG;Gordon, JI
通讯作者：
Gordon, JI
影响因子：
5.1
作者：
Bertin, Yolande;Girardeau, J. P.;Martin, Christine
通讯作者：
Martin, Christine