Are major histocompatibility complex molecules involved in the survival of naive CD4+ T cells?
Are major histocompatibility complex molecules involved in the survival of naive CD4+ T cells?
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幼稚CD4+ T细胞的存活中，主要的组织相容性复合物分子是否参与？
DOI：
10.1084/jem.20030963
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发表时间：
2003-10-06
期刊：
影响因子：
--
通讯作者：
Lantz O
中科院分区：
文献类型：
--
作者：
Grandjean I;Duban L;Bonney EA;Corcuff E;Di Santo JP;Matzinger P;Lantz O
主要组织相容性复合体（MHC）分子在幼稚T细胞的外周存活中的确切作用是有争议的，因为一些研究表明它们是至关重要的，而另一些研究表明它们不是。在这里，我们控制了早期研究中的一些不同特征，并分析了转移到MHC同基因、同种异体或MHC阴性环境中的幼稚CD 4 + T细胞的存活和扩增。我们发现转移到MHC阴性或同种异体环境中的幼稚T细胞通常无法存活，因为自然杀伤（NK）细胞的排斥和/或竞争，而不是无法识别特定的MHC等位基因。在不存在NK细胞的情况下，初始CD 4 + T细胞同样存活良好，而不管宿主的MHC类型如何。然而，有一个广泛的空间诱导的“稳态”扩张的MHC的要求。虽然最初的几次分裂发生在没有MHC分子的情况下，但细胞没有继续分裂或转变为CD 44 hi表型。令人惊讶的是，这种MHC的要求可以满足等位基因以外的限制单倍型。因此，空间诱导的扩增和存活是两种不同的现象，表现出不同的MHC要求。记忆性CD 4 + T细胞的存活和扩增完全不需要MHC分子，抑制了空间诱导的幼稚细胞扩增，表明这两个群体对外周小生境的需求并不独立。
The exact role of major histocompatibility complex (MHC) molecules in the peripheral survival of naive T cells is controversial, as some studies have suggested that they are critically required whereas others have suggested that they are not. Here we controlled for some of the features that differed among the earlier studies, and analyzed both the survival and expansion of naive CD4+ T cells transferred into MHC syngeneic, allogeneic, or MHC negative environments. We found that naive T cells transferred into MHC negative or allogeneic environments often fail to survive because of rejection and/or competition by natural killer (NK) cells, rather than failure to recognize a particular MHC allele. In the absence of NK cells, naive CD4+ T cells survived equally well regardless of the MHC type of the host. There was, however, an MHC requirement for extensive space-induced “homeostatic” expansion. Although the first few divisions occurred in the absence of MHC molecules, the cells did not continue to divide or transit to a CD44hi phenotype. Surprisingly, this MHC requirement could be satisfied by alleles other than the restricting haplotype. Therefore, space-induced expansion and survival are two different phenomena displaying different MHC requirements. Memory CD4+ T cells, whose survival and expansion showed no requirements for MHC molecules at all, dampened the space-induced expansion of naive cells, showing that the two populations are not independent in their requirements for peripheral niches.
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影响因子：
32.4
作者：
Ernst, B;Lee, DS;Surh, CD
通讯作者：
Surh, CD
DOI：
10.1084/jem.186.8.1223
发表时间：
1997-10-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brocker T
通讯作者：
Brocker T
DOI：
10.1084/jem.186.8.1269
发表时间：
1997-10-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kirberg J;Berns A;von Boehmer H
通讯作者：
von Boehmer H
DOI：
10.1084/jem.157.2.385
发表时间：
1983-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kärre K;Seeley JK;Eriksson E;Burton RC;Kiessling R
通讯作者：
Kiessling R
DOI：
10.1084/jem.174.5.969
发表时间：
1991-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gray D;Matzinger P
通讯作者：
Matzinger P