Phthalate mixtures in pregnancy, autistic traits, and adverse childhood behavioral outcomes.
Phthalate mixtures in pregnancy, autistic traits, and adverse childhood behavioral outcomes.
复制标题
妊娠期邻苯二甲酸酯混合物、自闭症特征和不良儿童行为结果。
DOI：
10.1016/j.envint.2020.106330
复制
发表时间：
2021-03
影响因子：
11.8
通讯作者：
Sathyanarayana, Sheela
中科院分区：
文献类型：
--
作者：
Day, Drew B.;Collett, Brent R.;Barrett, Emily S.;Bush, Nicole R.;Swan, Shanna H.;Nguyen, Ruby H. N.;Szpiro, Adam A.;Sathyanarayana, Sheela
产前暴露于多种邻苯二甲酸盐是普遍存在的，但很少有研究评估这些暴露与儿童自闭症特征和行为问题的关系。评估产前邻苯二甲酸盐混合物与儿童行为之间的累积关联，包括暴露时间和儿童性别对效果的影响。分析包括来自多中心妊娠队列婴儿发育与环境研究（TIDES）的501对母亲/儿童。研究人员在怀孕早期和晚期测量了9种母体尿邻苯二甲酸酯代谢物，并使用儿童行为评估系统（BASC-2）的综合T评分和社会反应量表（SRS-2）评估了4-5岁儿童的行为，BASC-2测量了儿童行为的几个维度，SRS-2测量了与自闭症特征一致的社会障碍。我们使用加权分位数和（WQS）回归来检查邻苯二甲酸盐混合物与行为结果之间的妊娠期特异性关联。已知全样本95% WQS置信区间是反保守的，因此我们使用置换检验计算了验证性p值。用分层分析检验了性别对效果的影响。妊娠早期邻苯二甲酸盐混合物浓度每增加五分之一，男女的SRS-2总分均增加（系数= 1.0，验证性p = 0.01），适应技能下降（系数= - 1.0，验证性p = 0.06）。在性别分层分析中，怀孕早期邻苯二甲酸盐混合物与男孩（系数= 1.2，验证性p = 0.04）和女孩（系数= 1.0，验证性p = 0.10）的SRS-2总分升高相关，女孩（系数= - 1.5，验证性p = 0.06）的BASC-2适应技能得分较差相关，而怀孕晚期邻苯二甲酸盐混合物与男孩（系数= 1.3，验证性p = 0.03）的BASC-2外化得分升高相关。我们的研究结果表明，产前邻苯二甲酸盐混合物与儿童行为的多个方面之间存在累积的不良关联。
Prenatal exposure to multiple phthalates is ubiquitous, and yet few studies have evaluated these exposures as a mixture in relation to child autistic traits and behavioral problems. To assess cumulative associations between prenatal phthalate mixtures and child behaviors, including effect modification by exposure timing and child sex. Analyses included 501 mother/child pairs from the multicenter pregnancy cohort The Infant Development and Environment Study (TIDES). Nine maternal urinary phthalate metabolites were measured in early and late pregnancy, and behavior was assessed at ages 4–5 years using composite T scores for the Behavioral Assessment System for Children (BASC-2), which measures several dimensions of child behavior, and the Social Responsiveness Scale (SRS-2), which measures social impairment consistent with autistic traits. We utilized weighted quantile sum (WQS) regressions to examine pregnancy period-specific associations between phthalate mixtures and behavioral outcomes. Full-sample 95% WQS confidence intervals are known to be anticonservative, so we calculated a confirmatory p-value using a permutation test. Effect modification by sex was examined with stratified analyses. A one-quintile increase in the early pregnancy phthalate mixture was associated with increased SRS-2 total score (coefficient = 1.0, confirmatory p = 0.01) and worse adaptive skills (coefficient = −1.0, confirmatory p = 0.06) in both sexes. In sex-stratified analyses, the early pregnancy phthalate mixture was associated with increased SRS-2 total score in boys (coefficient = 1.2, confirmatory p = 0.04) and girls (coefficient = 1.0, confirmatory p = 0.10) and worse BASC-2 adaptive skills score in girls (coefficient = −1.5, confirmatory p = 0.06), while the late pregnancy phthalate mixture was associated with increased BASC-2 externalizing score in boys (coefficient = 1.3, confirmatory p = 0.03). Our results suggest cumulative adverse associations between prenatal phthalate mixtures and multiple facets of childhood behavior.
登录
查看更多内容
影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
8.3
作者：
Huang, Han-Bin;Kuo, Po-Hsiu;Wang, Shu-Li
通讯作者：
Wang, Shu-Li
影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.6
作者：
FERGUSSON, DM;LYNSKEY, MT;HORWOOD, LJ
通讯作者：
HORWOOD, LJ