Do biofilm formation and interactions with human cells explain the clinical success of Acinetobacter baumannii?
Do biofilm formation and interactions with human cells explain the clinical success of Acinetobacter baumannii?
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DOI：
10.1371/journal.pone.0010732
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发表时间：
2010-05-20
期刊：
影响因子：
3.7
通讯作者：
Nibbering P
中科院分区：
文献类型：
--
作者：
de Breij A;Dijkshoorn L;Lagendijk E;van der Meer J;Koster A;Bloemberg G;Wolterbeek R;van den Broek P;Nibbering P
抗生素耐药性的急剧增加和最近在战争创伤患者中的表现突显了鲍曼不动杆菌作为医院病原体的威胁。尽管有许多关于鲍曼不动杆菌流行的报道，但人们对鲍曼不动杆菌的致病性知之甚少。这项研究的目的是深入了解可能解释鲍曼不动杆菌临床成功的因素。我们比较了一大组描述良好的鲍曼不动杆菌的生物膜形成、对人类细胞的黏附和炎症细胞因子的诱导，并将这些特征与其他临床上相关性较小的不动杆菌物种进行了比较。结果表明，生物膜的形成和对呼吸道上皮细胞的黏附在不同物种之间差异很大，但在物种之间没有差异。然而，接触鲍曼不动杆菌菌株时，呼吸道上皮细胞和培养的人巨噬细胞产生的炎性细胞因子明显少于不常引起感染的朱尼弧菌菌株。弱炎症反应的诱导可能为鲍曼不动杆菌在患者体内的持续存在提供线索。
The dramatic increase in antibiotic resistance and the recent manifestation in war trauma patients underscore the threat of Acinetobacter baumannii as a nosocomial pathogen. Despite numerous reports documenting its epidemicity, little is known about the pathogenicity of A. baumannii. The aim of this study was to obtain insight into the factors that might explain the clinical success of A. baumannii. We compared biofilm formation, adherence to and inflammatory cytokine induction by human cells for a large panel of well-described strains of A. baumannii and compared these features to that of other, clinically less relevant Acinetobacter species. Results revealed that biofilm formation and adherence to airway epithelial cells varied widely within the various species, but did not differ among the species. However, airway epithelial cells and cultured human macrophages produced significantly less inflammatory cytokines upon exposure to A. baumannii strains than to strains of A. junii, a species infrequently causing infection. The induction of a weak inflammatory response may provide a clue to the persistence of A. baumannii in patients.
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