Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU.
Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU.
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作者：
Sussman G;Abuzakouk M;Bérard F;Canonica W;Oude Elberink H;Giménez-Arnau A;Grattan C;Hollis K;Hunter S;Knulst A;Lacour JP;Lynde C;Marsland A;McBride D;Maurer M;Nakonechna A;Ortiz de Frutos J;Reynolds M;Sweeney C;Tian H;Weller K;Wolin D;Balp MM
ASSURE-CSU显示医生和患者报告的血管性水肿存在差异。进行了这项事后分析，以评价研究人群中血管性水肿的实际发生率，并探索有和无血管性水肿患者之间的差异。这项国际观察性研究评估了673例控制不佳的慢性自发性荨麻疹（CSU）患者。医生从病历中提取血管性水肿数据，并与患者报告的数据进行比较。是-血管性水肿类别中的患者在病历和患者报告来源中报告了血管性水肿。对于无血管性水肿类别的患者，病历和患者报告来源均未报告血管性水肿。未对准类别中的患者仅在一个来源中报告了血管性水肿。对CSU活动、健康相关生活质量（HRQoL）、生产力和医疗资源利用（HCRU）指标进行了有血管性水肿和无血管性水肿类别之间的统计学比较。回归分析探讨了皮肤病生活质量指数（DLQI）评分和血管性水肿之间的关系，调整了重要的协变量。在可评价患者中，分别有259例（40.3%）、173例（26.9%）和211例（32.8%）属于是血管性水肿、无血管性水肿和未对准类别。有血管性水肿患者的CSU活动和对HRQoL、生产力和HCRU的影响大于无血管性水肿患者。经协变量校正后，血管性水肿患者的平均DLQI评分显著高于无血管性水肿患者（9.88 vs 7.27，P <0.001）（表明HRQoL较差）。错位类别的结果与是相似-所有结局均为血管性水肿。CSU中的血管性水肿似乎报告不足，但与无血管性水肿相比，对HRQoL、日常活动、HCRU和工作有显著的负面影响。
ASSURE‐CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema. This international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient‐reported data. Patients in the Yes‐angioedema category had angioedema reported in the medical record and a patient‐reported source. For those in the No‐angioedema category, angioedema was reported in neither the medical record nor a patient‐reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes‐angioedema and No‐angioedema categories were conducted for measures of CSU activity, health‐related quality of life (HRQoL), productivity and healthcare resource utilization (HCRU). Regression analyses explored the relationship between Dermatology Life Quality Index (DLQI) score and angioedema, adjusting for important covariates. Among evaluable patients, 259 (40.3%), 173 (26.9%) and 211 (32.8%) were in the Yes‐angioedema, No‐angioedema and Misaligned category, respectively. CSU activity and impact on HRQoL, productivity, and HCRU was greater for Yes‐angioedema patients than No‐angioedema patients. After covariate adjustment, mean DLQI score was significantly higher (indicating worse HRQoL) for patients with angioedema versus no angioedema (9.88 vs 7.27, P < .001). The Misaligned category had similar results with Yes‐angioedema on all outcomes. Angioedema in CSU seems to be under‐reported but has significant negative impacts on HRQoL, daily activities, HCRU and work compared with no angioedema.
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影响因子：
12.4
作者：
Maurer M;Abuzakouk M;Bérard F;Canonica W;Oude Elberink H;Giménez-Arnau A;Grattan C;Hollis K;Knulst A;Lacour JP;Lynde C;Marsland A;McBride D;Nakonechna A;Ortiz de Frutos J;Proctor C;Sussman G;Sweeney C;Tian H;Weller K;Wolin D;Balp MM
通讯作者：
Balp MM
影响因子：
12.4
作者：
Baiardini, I;Pasquali, M;Canonica, GW
通讯作者：
Canonica, GW
DOI：
10.1111/jdv.14384
发表时间：
2017-10-01
影响因子：
9.2
作者：
Finlay, A. Y.;Kaplan, A. P.;Maurer, M.
通讯作者：
Maurer, M.
DOI：
10.1111/jdv.14075
发表时间：
2017-06-01
影响因子：
9.2
作者：
Maurer, M.;Sofen, H.;Bernstein, J. A.
通讯作者：
Bernstein, J. A.
影响因子：
12.4
作者：
Mlynek, A.;Magerl, M.;Maurer, M.
通讯作者：
Maurer, M.