Radiolabeled Angiogenesis-Targeting Croconaine Nanoparticles for Trimodality Imaging Guided Photothermal Therapy of Glioma.
Radiolabeled Angiogenesis-Targeting Croconaine Nanoparticles for Trimodality Imaging Guided Photothermal Therapy of Glioma.
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DOI：
10.1021/acsanm.8b00195
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发表时间：
2018-04-27
影响因子：
5.9
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Tang L;Sun X;Liu N;Zhou Z;Yu F;Zhang X;Sun X;Chen X
为了满足有效治疗诊断学的标准，赋予内在治疗和成像特性的生物相容性纳米医学获得了非凡的动力。在这项研究中，一个超稳定的近红外（NIR）染料croconaine（CR 780）工程与精氨酸-甘氨酸-天冬氨酸（RGD）肽和聚乙二醇（PEG），然后自组装成均匀的纳米粒子（NPs）。这些RGD-CR 780-PEG 5 K组装件通过简易标准Iodo-Gen方法用125 I进行放射性标记。通过单光子发射计算机断层扫描（SPECT）/CT和NIR荧光成像证明，所得[125 I] RGD-CR 780-PEG 5 K NP在表达αvβ3整联蛋白的胶质母细胞瘤中显示有效蓄积。更重要的是，高分辨率光声成像显示，这些纳米颗粒选择性地靶向血管生成肿瘤血管。[125 I] RGD-CR 780-PEG 5 K纳米粒具有良好的肿瘤选择性积聚和高光热转换效率，可在相对较低的激光能量（0.5 W/cm 2）下彻底消融肿瘤并抑制肿瘤复发。总的来说，这项工作提供了一种适当的方法来制造肿瘤靶向的多模式纳米治疗剂，为精确成像和癌症治疗提供了巨大的机会。
To meet the criteria of effective theranostics, biocompatible nanomedicine endowing intrinsic therapeutic and imaging properties have gained extraordinary momentum. In this study, an ultra-stable near-infrared (NIR) dye croconaine (CR780) was engineered with arginine-glycine-aspartic acid (RGD) peptide and polyethylene glycol (PEG), which was then self-assembled into uniform nanoparticles (NPs). These RGD-CR780-PEG5K assemblies were radiolabeled with 125I through a facile standard Iodo-Gen method. The resulting [125I]RGD-CR780-PEG5K NPs showed effective accumulation in αvβ3 integrin expressing glioblastoma, as evidenced by single photon emission computed tomography (SPECT)/CT and NIR fluorescence imaging. More importantly, high-resolution photoacoustic imaging revealed that these NPs selectively targeted to angiogenic tumor vessels. With the favorable tumor selective accumulation and high photothermal conversion efficiency, the [125I]RGD-CR780-PEG5K NPs allowed thorough tumor ablation and inhibition of tumor relapse at a relatively low laser energy (0.5 W/cm2). Overall, this work offers a proper methodology to fabricate tumor-targeted multi-modal nanotheranostic agents, providing great opportunity for precision imaging and cancer therapy.
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DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
8.4
作者：
Spence, Graeme T.;Hartland, Gregory V.;Smith, Bradley D.
通讯作者：
Smith, Bradley D.
具有超快光响应速度和优越机械性能的近红外发色团功能化软执行器
影响因子：
15
作者：
Liu, Li;Liu, Mei-Hua;Yang, Hong
通讯作者：
Yang, Hong
影响因子：
12.4
作者：
Chen K;Chen X
通讯作者：
Chen X
影响因子：
10.8
作者：
Lin X;Xie J;Niu G;Zhang F;Gao H;Yang M;Quan Q;Aronova MA;Zhang G;Lee S;Leapman R;Chen X
通讯作者：
Chen X