Tissue engineered nerve constructs: where do we stand?
Tissue engineered nerve constructs: where do we stand?
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DOI：
10.1111/j.1582-4934.2006.tb00401.x
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发表时间：
2006-04
影响因子：
5.3
通讯作者：
Evans GR
中科院分区：
文献类型：
--
作者：
Chalfoun CT;Wirth GA;Evans GR
在巨大的临床需求的推动下，对周围神经再生的兴趣已成为组织工程领域研究和增长领域的主要焦点。虽然使用自体供体神经桥接周围缺损仍然是当今的黄金标准，但它仍然与供体部位的高发病率和缺乏完全恢复有关。这要求研究开发仿生结构作为替代方案。基于当前的概念，这篇综述总结了各种方法，包括不同的细胞外基质、支架和生长因子，这些方法已被证明可以促进雪旺细胞的迁移和增殖。由于这些概念单独存在是不够的，尽管每个概念在促进神经再生方面越来越受到关注，但需要确定各种组合以达到和谐的平衡。必须纳入组织工程神经构造的其他因素也是未知的，需要进一步的研究工作。看来未来的方向或许能让我们确定“缺失的一环”。
Driven by enormous clinical need, interest in peripheral nerve regeneration has become a prime focus of research and area of growth within the field of tissue engineering. While using autologous donor nerves for bridging peripheral defects remains today's gold standard, it remains associated with high donor site morbidity and lack of full recovery. This dictates research towards the development of biomimetic constructs as alternatives. Based on current concepts, this review summarizes various approaches including different extracellular martices, scaffolds, and growth factors that have been shown to promote migration and proliferation of Schwann cells. Since neither of these concepts in isolation is enough, although each is gaining increased interest to promote nerve regeneration, various combinations will need to be identified to strike a harmonious balance. Additional factors that must be incorporated into tissue engineered nerve constructs are also unknown and warrant further research efforts. It seems that future directions may allow us to determine the “missing link”.
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影响因子：
3.3
作者：
Beier, JP;Kneser, U;Bach, AD
通讯作者：
Bach, AD
影响因子：
--
作者：
Evans, GRD
通讯作者：
Evans, GRD
DOI：
10.1023/a:1015410023132
发表时间：
1997-08-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Fujimoto, E;Mizoguchi, A;Ide, C
通讯作者：
Ide, C
DOI：
10.1001/archotol.124.10.1081
发表时间：
1998-10-01
影响因子：
--
作者：
Hadlock, T;Elisseeff, J;Cheney, M
通讯作者：
Cheney, M
影响因子：
3.4
作者：
Dezawa, M;Takahashi, I;Sawada, H
通讯作者：
Sawada, H