Multivariate pattern analysis reveals anatomical connectivity differences between the left and right mesial temporal lobe epilepsy.
Multivariate pattern analysis reveals anatomical connectivity differences between the left and right mesial temporal lobe epilepsy.
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多变量模式分析揭示了左右内侧颞叶癫痫之间的解剖连接差异。
DOI：
10.1016/j.nicl.2014.12.018
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发表时间：
2015
影响因子：
4.2
通讯作者：
Hu, Dewen
中科院分区：
文献类型：
--
作者：
Fang, Peng;An, Jie;Zeng, Ling-Li;Shen, Hui;Chen, Fanglin;Wang, Wensheng;Qiu, Shijun;Hu, Dewen
关键词：
先前的研究已经证实了左右内侧颞叶癫痫（mTLE）的临床症状和功能性脑网络组织的差异，但在功能差异背后的解剖连通性差异仍未被表征。我们使用弥散张量成像检查了43例（22例左，21例右）伴有海马硬化的mTLE患者和39例健康对照者。构建各被试全脑解剖网络后，应用多元模式分析对左、右颞叶颞叶进行分类，提取左、右颞叶颞叶患者解剖连通性差异。分类结果显示，左侧mTLE与右侧mTLE的准确率为93.0%，左侧mTLE与对照组的准确率为93.4%，右侧mTLE与对照组的准确率为90.0%。与右侧颞叶颞叶相比，左侧颞叶皮层-边缘网络和小脑的连接模式不同。大多数最具鉴别性的解剖连接位于皮质边缘网络和小脑内部或跨越皮质边缘网络和小脑，从而表明这些与疾病相关的解剖网络改变可能导致左右颞叶之间的一部分情感和记忆缺陷复合体。眶额回、扣带皮层、海马和海马旁回具有较高的分类能力，可能在mTLE的病理生理中发挥重要作用。目前的研究表明，左侧和右侧mTLE之间的解剖连通性差异可能有潜力作为神经成像生物标志物，指导左右mTLE的个性化诊断。左侧mTLE与右侧mTLE的识别准确率为93.0%。左、右颞叶在皮质边缘网络和小脑中表现出不同的连通性模式。解剖网络的差异可能解释了左右颞叶颞叶情绪和记忆缺陷的差异。
Previous studies have demonstrated differences of clinical signs and functional brain network organizations between the left and right mesial temporal lobe epilepsy (mTLE), but the anatomical connectivity differences underlying functional variance between the left and right mTLE remain uncharacterized. We examined 43 (22 left, 21 right) mTLE patients with hippocampal sclerosis and 39 healthy controls using diffusion tensor imaging. After the whole-brain anatomical networks were constructed for each subject, multivariate pattern analysis was applied to classify the left mTLE from the right mTLE and extract the anatomical connectivity differences between the left and right mTLE patients. The classification results reveal 93.0% accuracy for the left mTLE versus the right mTLE, 93.4% accuracy for the left mTLE versus controls and 90.0% accuracy for the right mTLE versus controls. Compared with the right mTLE, the left mTLE exhibited a different connectivity pattern in the cortical-limbic network and cerebellum. The majority of the most discriminating anatomical connections were located within or across the cortical-limbic network and cerebellum, thereby indicating that these disease-related anatomical network alterations may give rise to a portion of the complex of emotional and memory deficit between the left and right mTLE. Moreover, the orbitofrontal gyrus, cingulate cortex, hippocampus and parahippocampal gyrus, which exhibit high discriminative power in classification, may play critical roles in the pathophysiology of mTLE. The current study demonstrated that anatomical connectivity differences between the left mTLE and the right mTLE may have the potential to serve as a neuroimaging biomarker to guide personalized diagnosis of the left and right mTLE. The left mTLE can be identified from the right mTLE with 93.0% accuracy. The left mTLE and right mTLE exhibited a different connectivity pattern in cortical-limbic network and cerebellum. Anatomical network differences may account for the variance of emotional and memory deficit between the left and right mTLE.
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影响因子：
3.7
作者：
Hagmann, Patric;Kurant, Maciej;Gigandet, Xavier;Thiran, Patrick;Wedeen, Van J.;Meuli, Reto;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe
影响因子：
4.8
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
通讯作者：
Tracy, Joseph I.
影响因子：
7.5
作者：
CORTES, C;VAPNIK, V
通讯作者：
VAPNIK, V
影响因子：
5.6
作者：
Engel, J
通讯作者：
Engel, J
影响因子：
2.6
作者：
Hadland, KA;Rushworth, MFS;Passingham, RE
通讯作者：
Passingham, RE