Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss.
Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss.
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单侧突发性感音神经性听力损失患者的脑血流模式变化
DOI：
10.3389/fnins.2022.856710
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发表时间：
2022
影响因子：
4.3
通讯作者：
Ma G
中科院分区：
文献类型：
--
作者：
Chen Y;Li H;Liu B;Gao W;Yang A;Lv K;Xia H;Zhang W;Yu H;Liu J;Liu X;Wang Y;Han H;Ma G
本研究分析了单侧突发性感音神经性听力损失（SSNHL）患者与健康对照者（HCs）之间脑血流量（CBF）的差异。我们还探究了左侧和右侧SSNHL（lSSNHL和rSSNHL）患者以及健康对照者在听觉相关区域的脑血流量差异。我们进一步探讨了单侧SSNHL的特征与脑血流量变化之间的相关性。
研究招募了36名单侧SSNHL患者（男性15名，女性21名，年龄40.39 ± 13.42岁）和36名健康对照者（男性15名，女性21名，年龄40.39 ± 14.11岁）。采用动脉自旋标记（ASL）技术采集并分析脑血流量图像。使用CereFlow软件对ASL数据进行后处理，以获取脑图谱（BNA）内246个子区域的脑血流量值。采用两样本t检验比较SSNHL患者与健康对照者之间的脑血流量差异。采用单因素方差分析或Kruskal - Wallis检验比较三组（lSSNHL、rSSNHL和健康对照者）在听觉相关区域的脑血流量差异。然后，计算脑血流量变化与特定临床特征之间的相关性。
SSNHL患者双侧额中回（MFG，MFG_7_1和MFG_7_3）、对侧中央前回（PrG，PrG_6_3）以及双侧顶上小叶（SPL，双侧SPL_5_1、SPL_5_2和同侧SPL_5_4）的脑血流量降低，p < 0.0002。与健康对照者相比，单侧SSNHL患者双侧眶回（OrG，OrG_6_5）、双侧颞下回（ITG，对侧ITG_7_1和双侧ITG_7_7）的相对脑血流量增加，p < 0.0002。lSSNHL患者左侧BA21尾部（p = 0.02）和左侧BA37背外侧（p = 0.047）出现脑血流量异常。我们发现，SSNHL患者同侧MFG_7_1的脑血流量与耳鸣视觉模拟量表（VAS）评分呈正相关（r = 0.485，p = 0.008）。
我们的初步研究探索了单侧SSNHL患者在听觉相关区域和非听觉区域的脑血流量模式变化，这表明SSNHL患者可能存在注意力下降以及一些感觉代偿现象。这些发现有助于增进我们对单侧SSNHL潜在病理生理机制的理解。
This study analyzed the differences in the cerebral blood flow (CBF) between unilateral Sudden Sensorineural Hearing Loss (SSNHL) patients and healthy controls (HCs). We also investigated CBF differences in auditory-related areas in patients with left- and right-sided SSNHL (lSSNHL and rSSNHL) and HCs. We further explore the correlation between unilateral SSNHL characteristics and changes in the CBF. 36 patients with unilateral SSNHL (15 males and 21 females, 40.39 ± 13.42 years) and 36 HCs (15 males and 21 females, 40.39 ± 14.11 years) were recruited. CBF images were collected and analyzed using arterial spin labeling (ASL). CereFlow software was used for the post-processing of the ASL data to obtain the CBF value of 246 subregions within brainnetome atlas (BNA). The Two-sample t-test was used to compare CBF differences between SSNHL patients and HCs. One-way ANOVA or Kruskal-Wallis test was used to compare the CBF difference of auditory-related areas among the three groups (lSSNHL, rSSNHL, and HCs). Then, the correlation between CBF changes and specific clinical characteristics were calculated. The SSNHL patients exhibited decreased CBF in the bilateral middle frontal gyrus (MFG, MFG_7_1 and MFG_7_3), the contralateral precentral gyrus (PrG, PrG_6_3) and the bilateral superior parietal lobule (SPL, bilateral SPL_5_1, SPL_5_2, and ipsilateral SPL_5_4), p < 0.0002. Compared with HCs, unilateral SSNHL patients exhibited increased rCBF in the bilateral orbital gyrus (OrG, OrG_6_5), the bilateral inferior temporal gyrus (ITG, contralateral ITG_7_1 and bilateral ITG_7_7), p < 0.0002. lSSNHL showed abnormal CBF in left BA21 caudal (p = 0.02) and left BA37 dorsolateral (p = 0.047). We found that the CBF in ipsilateral MFG_7_1 of SSNHL patients was positively correlated with tinnitus Visual Analog Scale (VAS) score (r = 0.485, p = 0.008). Our preliminary study explored CBF pattern changes in unilateral SSNHL patients in auditory-related areas and non-auditory areas, suggesting that there may exist reduced attention and some sensory compensation in patients with SSNHL. These findings could advance our understanding of the potential pathophysiology of unilateral SSNHL.
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DOI：
10.1016/j.nicl.2017.10.029
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
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DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
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作者：
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Jiang T
影响因子：
4.3
作者：
Luan, Ying;Wang, Congxiao;Teng, Gao-Jun
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DOI：
10.1016/j.ijdevneu.2019.05.009
发表时间：
2019-08-01
影响因子：
1.8
作者：
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通讯作者：
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影响因子：
2.7
作者：
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