A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task.
A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task.
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DOI：
10.1016/j.nicl.2017.10.029
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
De Volder AG
中科院分区：
文献类型：
--
作者：
Araneda R;Renier L;Dricot L;Decat M;Ebner-Karestinos D;Deggouj N;De Volder AG
由于我们最近在行为任务中表明，自上而下的认知控制在耳鸣患者中发生了特别改变，因此我们希望在耳鸣患者中建立执行功能受损与额叶皮层大脑改变之间的联系。使用功能磁共振成像 (fMRI)，我们监测了 16 名耳鸣患者 (TP) 及其对照受试者 (CS) 在执行空间斯特鲁普任务时听觉和视觉方面的大脑活动变化。我们观察到 TP 与 CS 的不同之处在于它们对背外侧前额叶皮层（dlPFC，BA46）、扣带回和腹内侧前额叶皮层（vmPFC，BA10）的功能募集。无论感觉方式如何，耳鸣参与者在干扰条件下的这种募集均高于对照组。此外，右侧 dlPFC 和 vmPFC 的大脑活动水平与 TP 中 Stroop 任务的表现相关。由于 TP 中较差的执行功能与前额皮质改变之间存在直接联系，我们假设自上而下的认知控制受损后缺乏抑制性调节可能会通过阻碍习惯机制来维持耳鸣。由前额叶皮层改变引起的执行功能缺陷将是耳鸣产生和持续的关键因素。耳鸣患者表现出自上而下的认知控制的选择性损害。耳鸣患者的前额皮质活动发生改变。认知控制缺陷有助于解释耳鸣的持续存在。这一发现为耳鸣的成功康复开辟了新的视角。
Since we recently showed in behavioural tasks that the top-down cognitive control was specifically altered in tinnitus sufferers, here we wanted to establish the link between this impaired executive function and brain alterations in the frontal cortex in tinnitus patients. Using functional magnetic resonance imaging (fMRI), we monitored the brain activity changes in sixteen tinnitus patients (TP) and their control subjects (CS) while they were performing a spatial Stroop task, both in audition and vision. We observed that TP differed from CS in their functional recruitment of the dorsolateral prefrontal cortex (dlPFC, BA46), the cingulate gyrus and the ventromedial prefrontal cortex (vmPFC, BA10). This recruitment was higher during interference conditions in tinnitus participants than in controls, whatever the sensory modality. Furthermore, the brain activity level in the right dlPFC and vmPFC correlated with the performance in the Stroop task in TP. Due to the direct link between poor executive functions and prefrontal cortex alterations in TP, we postulate that a lack of inhibitory modulation following an impaired top-down cognitive control may maintain tinnitus by hampering habituation mechanisms. This deficit in executive functions caused by prefrontal cortex alterations would be a key-factor in the generation and persistence of tinnitus. Tinnitus patients show a selective impairment of their top-down cognitive control. Tinnitus patients show altered activity in the prefrontal cortex. The cognitive control deficit contributes to explain the maintaining of tinnitus. This finding opens new perspectives for successful rehabilitation of tinnitus.
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影响因子：
8.2
作者：
Adjamian, Peyman;Hall, Deborah A.;Palmer, Alan R.;Allan, Thomas W.;Langers, Dave R. M.
通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1018466108
发表时间：
2011-05-17
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.7
作者：
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