Aberrant degree centrality profiles during rumination in major depressive disorder.
Aberrant degree centrality profiles during rumination in major depressive disorder.
复制标题
重度抑郁症患者反刍思维过程中异常的度中心性特征 。
DOI：
10.1002/hbm.26510
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发表时间：
2023-12-01
影响因子：
4.8
通讯作者：
Liu, Yan-Song
中科院分区：
文献类型：
--
作者：
Jia, Feng-Nan;Chen, Xiao;Du, Xiang-Dong;Tang, Zhen;Ma, Xiao-Yun;Ning, Tian-Tian;Zou, Si-Yun;Zuo, Shang-Fu;Li, Hui-Xian;Cui, Shi-Xian;Deng, Zhao-Yu;Fu, Jia-Lin;Fu, Xiao-Qian;Huang, Yue-Xiang;Li, Xue-Ying;Lian, Tao;Liao, Yi-Fan;Liu, Li-Li;Lu, Bin;Wang, Yan;Wang, Yu-Wei;Wang, Zi-Han;Ye, Gang;Zhang, Xin-Zhu;Zhu, Hong-Liang;Quan, Chuan-Sheng;Sun, Hong-Yan;Yan, Chao-Gan;Liu, Yan-Song
关键词：
反刍与重度抑郁症（MDD）的发作和维持密切相关。先前的神经影像学研究已经确定了自我报告的反刍特质与使用静息状态功能磁共振成像（MRI）的大脑区域网络之间的功能耦合之间的关联。然而，很少有人知道在积极反刍在MDD的神经回路机制。度中心性（DC）是一个简单的度量来表示网络整合，这对于更高阶的心理过程（如反刍）至关重要。在MRI扫描期间，MDD患者（N = 45）和健康对照组（HC，N = 46）完成了反刍状态任务。我们检查了组（MDD与HC）和条件（反刍与分心）对顶点DC的相互作用。我们进一步用Neurosynth和BrainMap表征了所识别的大脑区域的功能参与。还对识别的感兴趣区域进行了基于种子的网络功能连接（FC）分析。最后，在识别的感兴趣区域的网络FC和自我报告的扫描仪内影响水平之间进行探索性相关分析。我们发现，左额上级回（SFG）区域，通常与额眼区重叠，表现出显着的相互作用。进一步的分析显示，它参与执行功能。该区域、额顶叶和背侧注意网络（DAN）之间的FC也表现出显著的交互作用。此外，分心期间其FC到DAN与基线时的扫描仪内情感水平呈轻微显著负相关。我们的研究结果暗示了一个重要的作用，左侧SFG在反刍的潜在神经回路机制在MDD和提供新的证据反刍的概念化的执行控制受损。我们诱导重度抑郁症（MDD）患者进入一个连续的，积极的反刍状态，并在整个表面的程度中心性配置文件的特点。与分心相比，抑郁症患者在反刍时左额上级回的集中度降低，而健康对照组则表现出相反的模式。
Rumination is closely linked to the onset and maintenance of major depressive disorder (MDD). Prior neuroimaging studies have identified the association between self‐reported rumination trait and the functional coupling among a network of brain regions using resting‐state functional magnetic resonance imaging (MRI). However, little is known about the underlying neural circuitry mechanism during active rumination in MDD. Degree centrality (DC) is a simple metric to denote network integration, which is critical for higher‐order psychological processes such as rumination. During an MRI scan, individuals with MDD (N = 45) and healthy controls (HC, N = 46) completed a rumination state task. We examined the interaction effect between the group (MDD vs. HC) and condition (rumination vs. distraction) on vertex‐wise DC. We further characterized the identified brain region's functional involvement with Neurosynth and BrainMap. Network‐wise seed‐based functional connectivity (FC) analysis was also conducted for the identified region of interest. Finally, exploratory correlation analysis was conducted between the identified region of interest's network FCs and self‐reported in‐scanner affect levels. We found that a left superior frontal gyrus (SFG) region, generally overlapped with the frontal eye field, showed a significant interaction effect. Further analysis revealed its involvement with executive functions. FCs between this region, the frontoparietal, and the dorsal attention network (DAN) also showed significant interaction effects. Furthermore, its FC to DAN during distraction showed a marginally significant negative association with in‐scanner affect level at the baseline. Our results implicated an essential role of the left SFG in the rumination's underlying neural circuitry mechanism in MDD and provided novel evidence for the conceptualization of rumination in terms of impaired executive control. We induced individuals with major depressive disorder (MDD) into a continuous, active rumination state and characterized the degree centrality profiles across the surface. MDD patients showed reduced degree centrality in the left superior frontal gyrus during rumination compared to distraction, while the healthy controls showed the opposite pattern.
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DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
影响因子：
2.8
作者：
Chou T;Hooley JM;Camprodon JA
通讯作者：
Camprodon JA
影响因子：
4.7
作者：
Bessette KL;Jenkins LM;Skerrett KA;Gowins JR;DelDonno SR;Zubieta JK;McInnis MG;Jacobs RH;Ajilore O;Langenecker SA
通讯作者：
Langenecker SA
影响因子：
4.2
作者：
Johnson, Marcia K.;Nolen-Hoeksema, Susan;Levin, Yael
通讯作者：
Levin, Yael
影响因子：
5.3
作者：
Cai, Weidong;Ryali, Srikanth;Menon, Vinod
通讯作者：
Menon, Vinod