The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis.
The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis.
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DOI：
10.1242/dev.010447
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发表时间：
2007-09
期刊：
影响因子：
--
通讯作者：
Strutt D
中科院分区：
文献类型：
--
作者：
Bastock R;Strutt D
Cell migration is fundamental in both animal morphogenesis and disease. The migration of individual cells is relatively well-studied, however in vivo cells often remain joined by cell-cell junctions and migrate in cohesive groups. How such groups of cells coordinate their migration is poorly understood. The planar polarity pathway coordinates the polarity of non-migrating cells in epithelial sheets and is required for cell rearrangements during vertebrate morphogenesis. It is therefore a good candidate to play a role in collective migration of groups of cells. Drosophila border cell migration is a well-characterised and genetically tractable model of collective cell migration, during which a group of about 6-10 epithelial cells detaches from the anterior end of the developing egg chamber and migrates invasively towards the oocyte. We find that the planar polarity pathway promotes this invasive migration, acting both in the migrating cells themselves and in the non-migratory polar follicle cells they carry along. Disruption of planar polarity signalling causes abnormalities in actin rich processes on the cell surface and leads to less efficient migration. This is apparently due in part to loss of regulation of Rho GTPase activity by the planar polarity receptor Frizzled, which itself becomes localised to the migratory edge of the border cells. We conclude that during collective cell migration the planar polarity pathway can mediate communication between motile and non-motile cells, which enhances the efficiency of migration via the modulation of actin dynamics.
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影响因子：
11.8
作者：
Chen, X;Oh, SW;Hou, SX
通讯作者：
Hou, SX
影响因子：
7.5
作者：
Lecaudey, V;Gilmour, D
通讯作者：
Gilmour, D
影响因子：
10.5
作者：
Kinoshita, N;Iioka, H;Ueno, N
通讯作者：
Ueno, N
DOI：
10.1083/jcb.144.3.533
发表时间：
1999-02-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Niewiadomska P;Godt D;Tepass U
通讯作者：
Tepass U
影响因子：
64.5
作者：
Duchek, P;Somogyi, K;Rorth, P
通讯作者：
Rorth, P