Eyeblink classical conditioning in H.M.: delay and trace paradigms.

Eyeblink classical conditioning in H.M.: delay and trace paradigms.
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H.M. 中的眨眼经典条件反射:延迟和跟踪范例。

DOI:
10.1037//0735-7044.107.6.911
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发表时间:
1993
影响因子:
1.9
通讯作者:
Woodruff-Pak,DS
Woodruff-Pak,DS
中科院分区:
医学4区
文献类型:
--
作者:
Woodruff-Pak,DS

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HM是一位具有双侧内侧颞叶结构移除和严重健忘症的著名受试者,在400ms延迟和900ms跟踪范式下,进行了21次90次眨眼经典条件反射(EBCC)试验。另一名有颞叶病变的健忘症患者和两名正常对照组(NCSs)也接受了条件反射。所有受试者的习得都发生在这两种范式中。延迟范式中的习得在HM组中延长(可能是由于他的小脑退化导致的),但在第二个健忘症受试者中没有。遗忘症受试者和NCSs在轨迹中比在延迟范式中表现出更快的习得速度。在最初的EBCC的两年后,HM在跟踪范式中达到学习标准的次数是实验的十分之一。HM没有表现出对实验者、仪器、指令或程序的回忆。结果表明,人类可以在海马体被彻底切除的情况下,在400毫秒的延迟和900毫秒的EBCC范例中保持条件。
HM, a well-known subject with bilateral removal of medial-temporal–lobe structures and profound amnesia, performed eyeblink classical conditioning (EBCC) for 21 90-trial sessions in the 400-ms delay and 900-ms trace paradigms. A 2nd amnesic subject with temporal lobe lesions and 2 normal control subjects (NCSs) were also conditioned. Acquisition occurred in both paradigms for all subjects. Acquisition in the delay paradigm was prolonged in HM (perhaps because of his cerebellar degeneration in the vermis and hemispheres), but not in the 2nd amnesic subject. Amnesic subjects and NCSs showed more rapid acquisition in the trace than in the delay paradigm. Two years after initial EBCC, HM attained learning criterion in the trace paradigm in 1/10th as many trials. No recollection of the experimenters, apparatus, instructions, or procedure was manifested by HM Results suggest that humans can condition in the 400-ms delay and 900-ms trace EBCC paradigms with the hippocampus radically excised.
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