ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity.
ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity.
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DOI：
10.1038/s41467-018-04548-3
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发表时间：
2018-05-25
影响因子：
16.6
通讯作者：
Chadderton P
中科院分区：
文献类型：
--
作者：
Sollini J;Chapuis GA;Clopath C;Chadderton P
听觉皮层中的神经元对声音的开始和结束表现出不同的频率调谐，但ON和OFF感受野（RF）组织的原因和意义尚不清楚。在这里，我们表明，不同的ON和OFF频率调谐在很大程度上是不成熟的小鼠听觉皮层，因此是皮层发育的结果。模拟使用一个新的标准赫布可塑性模型的实现表明，自然交替的声音开始和偏移是足够的非重叠相邻的ON和OFF RF在皮层神经元的形成。我们的模型预测，ON/OFF RF安排有助于对调频音扫描的方向选择性，我们证实了神经元记录。这些数据表明，一个简单的和普遍接受的学习规则可以解释组织的ON和OFF的RF和方向选择性的发展中的听觉皮层。听觉皮层神经元表现出不同的频率调谐声音的开始和结束。在这里，作者表明，在发展过程中，ON-OFF感受野发散，占据相邻的频率范围，可能是他们的方向选择性响应调频扫描的基础。
Neurons in the auditory cortex exhibit distinct frequency tuning to the onset and offset of sounds, but the cause and significance of ON and OFF receptive field (RF) organisation are not understood. Here we demonstrate that distinct ON and OFF frequency tuning is largely absent in immature mouse auditory cortex and is thus a consequence of cortical development. Simulations using a novel implementation of a standard Hebbian plasticity model show that the natural alternation of sound onset and offset is sufficient for the formation of non-overlapping adjacent ON and OFF RFs in cortical neurons. Our model predicts that ON/OFF RF arrangement contributes towards direction selectivity to frequency-modulated tone sweeps, which we confirm by neuronal recordings. These data reveal that a simple and universally accepted learning rule can explain the organisation of ON and OFF RFs and direction selectivity in the developing auditory cortex. Auditory cortex neurons exhibit distinct frequency tuning to sound onset and offset. Here the authors demonstrate that during development ON-OFF receptive fields diverge to occupy adjacent frequency ranges that may underlie their direction selective responses to frequency modulated sweeps.
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影响因子：
64.8
作者：
Kremkow J;Jin J;Wang Y;Alonso JM
通讯作者：
Alonso JM
影响因子：
25
作者：
Clopath, Claudia;Buesing, Lars;Gerstner, Wulfram
通讯作者：
Gerstner, Wulfram
影响因子：
56.9
作者：
Kilgard, MP;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
3.7
作者：
Honma Y;Tsukano H;Horie M;Ohshima S;Tohmi M;Kubota Y;Takahashi K;Hishida R;Takahashi S;Shibuki K
通讯作者：
Shibuki K
DOI：
10.1523/jneurosci.2061-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chadderton P;Agapiou JP;McAlpine D;Margrie TW
通讯作者：
Margrie TW