Functional Connectivity of the Infant Human Brain: Plastic and Modifiable.
Functional Connectivity of the Infant Human Brain: Plastic and Modifiable.
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DOI：
10.1177/1073858416635986
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Gilmore JH
中科院分区：
文献类型：
--
作者：
Gao W;Lin W;Grewen K;Gilmore JH
婴儿期是人类大脑发育的关键和极其重要的时期。这一阶段的细微变化可能会随着不同发展过程的展开而大大放大，产生深远的影响。对婴儿大脑的结构和行为表现的研究成果丰硕。然而，直到功能连接功能磁共振成像(FcMRI)的出现，使得能够执行不同行为的特定功能脑机制仍然是未知的，这为探索婴儿在体内的功能脑发育提供了前所未有的机会。自诞生以来，婴儿脑功能连通性研究的一个新兴领域已经出现并在过去的十年中蓬勃发展。在这篇综述中，我们描述了(1)功能连接网络的正常发展及其与行为的关系的发现，以及(2)在人类生命的头两年，由于可识别的遗传和/或环境风险因素，标准功能连接发展的中断。文中还提出了婴儿fcMRI的技术考虑。我们希望巩固以前的发现，以便该领域能够更清晰地朝着基于fcMRI的客观方法的最终目标前进，以早期诊断/识别风险和评估早期干预措施，以优化在这一关键发展窗口中开发的功能连接网络。
Infancy is a critical and immensely important period in human brain development. Subtle changes during this stage may be greatly amplified with the unfolding of different developmental processes, exerting far-reaching consequences. Studies of the structure and behavioral manifestations of the infant brain are fruitful. However, the specific functional brain mechanisms that enable the execution of different behaviors remained elusive until the advent of functional connectivity fMRI (fcMRI), which provides an unprecedented opportunity to probe the infant functional brain development in vivo. Since its inception, a burgeoning field of infant brain functional connectivity study has emerged and thrived during the past decade. In this review, we describe (1) findings of normal development of functional connectivity networks and their relationships to behaviors and (2) disruptions of the normative functional connectivity development due to identifiable genetic and/or environmental risk factors during the first 2 years of human life. Technical considerations of infant fcMRI are also provided. It is our hope to consolidate previous findings so that the field can move forward with a clearer picture toward the ultimate goal of fcMRI-based objective methods for early diagnosis/identification of risks and evaluation of early interventions to optimize developing functional connectivity networks in this critical developmental window.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.3
作者：
Bandstra, Emmalee S.;Morrow, Connie E.;Accornero, Veronica H.
通讯作者：
Accornero, Veronica H.
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo
影响因子：
3.1
作者：
Afif, A.;Bouvier, R.;Mertens, P.
通讯作者：
Mertens, P.
影响因子：
3.2
作者：
Elton, Amanda;Gao, Wei
通讯作者：
Gao, Wei