Occupation and cancer in Britain.
Occupation and cancer in Britain.
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DOI：
10.1038/sj.bjc.6605637
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发表时间：
2010-04-27
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
对职业相关癌症的优先控制措施应以证据为基础。我们估计了英国目前的癌症负担可归因于国际癌症研究机构（IARC）第1组（已确定）和2A组（可能）致癌物的过去职业暴露。我们使用文献和国家数据来源的风险估计值来计算癌症死亡率和发病率的归因分数和数字，以估计暴露的比例。2005年，5.3%（8019例）的癌症死亡可归因于职业(男性，8.2%（6362例）；女性，2.3%(1657))。归因发病率估计为13679例（4.0%）癌症登记(男性，10063例（5.7%）；女性3616人（2.2%）。间皮瘤、鼻窦癌、肺癌、鼻咽癌、乳腺癌、非黑色素瘤皮肤癌、膀胱癌、食道癌、软组织肉瘤、喉癌和胃癌的职业归因分数超过2%。石棉、轮班工作、矿物油、太阳辐射、二氧化硅、柴油发动机废气、煤焦油和沥青、作为油漆工或焊工的职业、二恶英、环境烟草烟雾、氡、四氯乙烯、砷和强无机雾每种都有100个或更多的登记。癌症高发病率的行业和职业包括建筑、金属加工、个人和家庭服务、采矿、陆地运输、印刷/出版、零售/酒店/餐馆、公共管理/国防、农业和一些制造业。男性癌症登记的56%归因于建筑业的工作（主要是间皮瘤、肺癌、胃癌、膀胱癌和非黑色素瘤皮肤癌），而女性癌症登记的54%归因于轮班工作（乳腺癌）。这个项目是第一个详细量化英国因职业造成的癌症负担和死亡率的项目。它强调职业性接触以及过去曾接触致癌物剂的职业环境和工业区对人口癌症发病率和死亡率的影响；这可以与其他癌症原因的影响进行比较。减少风险战略应侧重于仍然发生这种接触的工作场所。
Prioritising control measures for occupationally related cancers should be evidence based. We estimated the current burden of cancer in Britain attributable to past occupational exposures for International Agency for Research on Cancer (IARC) group 1 (established) and 2A (probable) carcinogens. We calculated attributable fractions and numbers for cancer mortality and incidence using risk estimates from the literature and national data sources to estimate proportions exposed. 5.3% (8019) cancer deaths were attributable to occupation in 2005 (men, 8.2% (6362); women, 2.3% (1657)). Attributable incidence estimates are 13 679 (4.0%) cancer registrations (men, 10 063 (5.7%); women, 3616 (2.2%)). Occupational attributable fractions are over 2% for mesothelioma, sinonasal, lung, nasopharynx, breast, non-melanoma skin cancer, bladder, oesophagus, soft tissue sarcoma, larynx and stomach cancers. Asbestos, shift work, mineral oils, solar radiation, silica, diesel engine exhaust, coal tars and pitches, occupation as a painter or welder, dioxins, environmental tobacco smoke, radon, tetrachloroethylene, arsenic and strong inorganic mists each contribute 100 or more registrations. Industries and occupations with high cancer registrations include construction, metal working, personal and household services, mining, land transport, printing/publishing, retail/hotels/restaurants, public administration/defence, farming and several manufacturing sectors. 56% of cancer registrations in men are attributable to work in the construction industry (mainly mesotheliomas, lung, stomach, bladder and non-melanoma skin cancers) and 54% of cancer registrations in women are attributable to shift work (breast cancer). This project is the first to quantify in detail the burden of cancer and mortality due to occupation specifically for Britain. It highlights the impact of occupational exposures, together with the occupational circumstances and industrial areas where exposures to carcinogenic agents occurred in the past, on population cancer morbidity and mortality; this can be compared with the impact of other causes of cancer. Risk reduction strategies should focus on those workplaces where such exposures are still occurring.
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影响因子：
168.9
作者：
Lopez, Alan D.;Mathers, Colin D.;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
5
作者：
MIETTINE.OS
通讯作者：
MIETTINE.OS
影响因子：
10.4
作者：
Siemiatycki J;Richardson L;Straif K;Latreille B;Lakhani R;Campbell S;Rousseau MC;Boffetta P
通讯作者：
Boffetta P
影响因子：
13.8
作者：
Housman, TS;Feldman, SR;Chen, GJ
通讯作者：
Chen, GJ
影响因子：
4.5
作者：
通讯作者：
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