Articular cartilage deformation determined in an intact tibiofemoral joint by displacement-encoded imaging.

Articular cartilage deformation determined in an intact tibiofemoral joint by displacement-encoded imaging.
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关节软骨变形通过位移编码成像在完整的胫骨关节中确定。

DOI:
10.1002/mrm.21927
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发表时间:
2009-04
影响因子:
3.3
通讯作者:
Hu, Maury L.
Hu, Maury L.
中科院分区:
医学3区
文献类型:
--
作者:
Chan, Deva D.;Neu, Corey P.;Hu, Maury L.

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本研究使用位移编码成像与刺激回波(DENSE)和快速自旋回波(FSE),证明了在体外循环压缩和完整关节中关节软骨的位移和应变。变形和应变场表现出复杂和不均匀的模式。胫骨软骨在载荷方向上的位移范围为-1688至-1481 μm,股骨软骨在载荷方向上的位移范围为-1601至-764 μm。相应的菌株范围为-9.8%至0.7%和-4.3%至0.0%。位移和应变精度分别为65 μm和小于0.2%。位移编码磁共振成像能够以高精度确定完整关节的关节软骨中的不均匀位移和应变。这些不均匀的菌株的知识是至关重要的原位表征正常和病变组织,以及使用再生医学设计的修复结构的综合评价。
This study demonstrates the in vitro displacement and strain of articular cartilage in a cyclically-compressed and intact joint using displacement-encoded imaging with stimulated echoes (DENSE) and fast spin echo (FSE). Deformation and strain fields exhibited complex and heterogeneous patterns. The displacements in the loading direction ranged from −1688 to −1481 μm in the tibial cartilage and from −1601 to −764 μm in the femoral cartilage. Corresponding strains ranged from −9.8% to 0.7% and from −4.3% to 0.0%. The displacement and strain precision were determined to be 65 μm and less than 0.2%, respectively. Displacement-encoded magnetic resonance imaging is capable of determining the nonuniform displacements and strains in the articular cartilage of an intact joint to a high precision. Knowledge of these nonuniform strains is critical for the in situ characterization of normal and diseased tissue, as well as the comprehensive evaluation of repair constructs designed using regenerative medicine.
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