Prevalence and characteristics of HPV vaccine hesitancy among parents of adolescents across the US.
Prevalence and characteristics of HPV vaccine hesitancy among parents of adolescents across the US.
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DOI：
10.1016/j.vaccine.2020.06.074
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发表时间：
2020-08-27
期刊：
影响因子：
5.5
通讯作者：
Kempe, Allison
中科院分区：
文献类型：
--
作者：
Szilagyi, Peter G.;Albertin, Christina S.;Gurfinkel, Dennis;Saville, Alison W.;Vangala, Sitaram;Rice, John D.;Helmkamp, Laura;Zimet, Gregory D.;Valderrama, Rebecca;Breck, Abigail;Rand, Cynthia M.;Humiston, Sharon G.;Kempe, Allison
虽然许多临床医生会遇到拒绝接种HPV疫苗的家长或青少年，但人们对HPV疫苗犹豫不决的流行程度及其与疫苗接种的关系知之甚少。方法2019年4月，我们以全国在线面板（Knowledge panel®）为抽样框架，对11-17岁青少年家庭进行调查。我们使用经过验证的9项疫苗犹豫量表（VHS）评估HPV疫苗犹豫的患病率。我们使用多变量分析来评估与HPV疫苗犹豫相关的人口学因素。我们还评估了接受HPV疫苗的实际障碍以及障碍与犹豫之间的关系。最后，我们评估了HPV疫苗犹豫与HPV疫苗接受或拒绝的实际障碍之间的关系。结果4185名家长中有2177名（52%）完成了调查，合格（与青少年一起生活）的家长有2020名。使用VHS分值 > 3分（满分5分），23%的美国父母对HPV疫苗持犹豫态度。西班牙裔的犹豫率较低。至少五分之一的父母不同意HPV疫苗对他们的青少年有益，疫苗是有效的，可以预防HPV相关的癌症，或者他们遵循了青少年医疗保健提供者关于疫苗的建议。许多人担心疫苗的副作用和疫苗的新颖性。父母对疫苗持犹豫态度的青少年接种疫苗的可能性不到三分之一（RR = 0.29,95% CI 0.24, 0.35）或完成疫苗系列（RR = 0.29,95% CI 0.23, 0.36），并且由于父母对疫苗相关的担忧而拒绝接种疫苗的可能性高出6倍（RR = 6.09,95% CI = 5.26,7.04）。大多数实际障碍与疫苗接受独立相关，而与拒绝接种无关。结论shpv疫苗犹豫在全国范围内普遍存在，且与疫苗接种不足和拒绝接种密切相关。
BackgroundWhile many clinicians encounter parents or adolescents who refuse HPV vaccine, little is known about the prevalence of hesitancy for HPV vaccine nationally or its association with vaccination.MethodsIn April 2019, we surveyed families with adolescents 11–17 years using a national online panel (Knowledge Panel®) as the sampling frame. We assessed the prevalence of HPV vaccine hesitancy with the validated 9-item Vaccine Hesitancy Scale (VHS). We used multivariate analyses to assess demographic factors associated with HPV vaccine hesitancy. We also assessed practical barriers to receipt of HPV vaccine and the relationship between barriers and hesitancy. Finally, we evaluated the association between both HPV vaccine hesitancy and practical barriers on HPV vaccine receipt or refusal.Results2,177 parents out of 4,185 sampled (52%) completed the survey, 2,020 qualified (lived with adolescent). Using a VHS cut-off score > 3 out of 5 points, 23% of US parents were hesitant about HPV vaccine. Hesitancy was lower among those with Hispanic ethnicity. At least one out of five parents disagreed that the HPV vaccine is beneficial for their adolescent, that the vaccine is effective, protects against HPV-related cancers, or that they followed their adolescent’s health-care provider’s recommendation about the vaccine. Many were concerned about vaccine side effects and the novelty of the vaccine. Adolescents living with vaccine-hesitant parents were less than one-third as likely to have received the vaccine (RR = 0.29, 95% CI 0.24, 0.35) or completed the vaccine series (RR = 0.29, 95% CI 0.23, 0.36), and were 6-fold more likely to have refused the vaccine because of parental vaccine-related concerns (RR = 6.09, 95% CI = 5.26, 7.04). Most practical barriers were independently associated with vaccine receipt but not with vaccine refusal.ConclusionsHPV vaccine hesitancy is common nationally and strongly related to both under-vaccination and vaccine refusal.
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