Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.
Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.
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DOI：
10.1002/oby.23261
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Hivert MF
中科院分区：
文献类型：
--
作者：
Wu AJ;Aris IM;Rifas-Shiman SL;Oken E;Taveras EM;Chavarro JE;Hivert MF
We examined associations of central adiposity gain from mid-childhood to early adolescence with cardiometabolic health markers in early adolescence. We studied 620 participants in Project Viva. In mid-childhood (mean age 7.8 years) and early adolescence (12.9 years), we obtained waist circumference and dual energy X-ray absorptiometry-measured visceral adipose tissue (VAT), subcutaneous abdominal adipose tissue (SAAT), and trunk fat. We calculated central adiposity gain as change per year between visits. We collected cardiometabolic health markers including blood pressure, lipids, markers of insulin resistance, inflammation, and adipokines in early adolescence. Greater waist circumference gain was associated with higher log triglycerides (β 0.07 mg/dL; 95% CI 0.02, 0.13), log alanine aminotransferase (0.07 U/L; 0.03, 0.12), log high-sensitivity C-reactive protein (0.43 mg/L; 0.28, 0.58), and other cardiometabolic markers in early adolescence. Directly measured central adiposity gains were associated with higher systolic blood pressure z-score in early adolescence (VAT [0.13 SD units; 0.04, 0.23], SAAT [0.18 SD units; 0.04, 0.31], and trunk fat [0.21 SD units; 0.06, 0.36]). These associations were independent of baseline and change in total adiposity from mid-childhood to early adolescence. Monitoring central adiposity gain may enable identification and intervention in children vulnerable to developing cardiometabolic health risks.
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DOI：
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发表时间：
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