Abdominal obesity and metabolic syndrome burden in adolescents--Penn State Children Cohort study.
Abdominal obesity and metabolic syndrome burden in adolescents--Penn State Children Cohort study.
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DOI：
10.1016/j.jocd.2014.07.009
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发表时间：
2015-01
影响因子：
2.5
通讯作者：
Liao, Duanping
中科院分区：
文献类型：
--
作者：
He, Fan;Rodriguez-Colon, Sol;Fernandez-Mendoza, Julio;Vgontzas, Alexandros N.;Bixler, Edward O.;Berg, Arthur;Kawasawa, Yuka Imamura;Sawyer, Marjorie D.;Liao, Duanping
在以人群为基础的青少年样本中调查腹型肥胖与代谢综合征（MetS）负担之间的关系。我们使用的数据来自421名青少年，他们在宾夕法尼亚州立大学儿童队列研究中完成了随访检查。采用双能X线吸收法（DXA）评估腹部肥胖，通过男性/女性脂肪比（A/G比）、男性/全身脂肪比（A/W比）、内脏（VAT）和皮下脂肪（SAT）面积进行测量。连续代谢综合征评分（cMetS），计算为年龄和性别调整的标准化残差（Z评分）的5个既定的MetS组件的总和，用于评估MetS负担。使用线性回归模型分析DXA测量对cMetS和单个cMetS组分的影响。所有模型均根据年龄、种族、性别和全身肥胖进行调整。腹部肥胖与cMetS增加显著相关。A/G比、A/W比、VAT面积和SAT面积每增加1个标准差，cMetS分别增加1.34（SE=0.17）、1.25（SE=0.19）、1.67（SE=0.17）和1.84（SE=0.20）个单位。在单个组分水平上，观察到腹部肥胖与胰岛素抵抗之间的最强关联，而不是基于脂质或基于血压的组分。VAT和SAT对胰岛素抵抗的影响比基于android比率的DXA测量更大。腹型肥胖与青少年人群中较高的代谢负荷相关。腹型肥胖与胰岛素抵抗指标之间的相关性最强，表明腹型肥胖对青少年胰岛素抵抗的关键影响是代谢负荷。
To investigate the association between abdominal obesity and metabolic syndrome (MetS) burden in a population-based sample of adolescents. We used the data from 421 adolescents who completed the follow-up examination in the Penn State Children Cohort study. Dual-energy x-ray absorptiometry (DXA) was used to assess abdominal obesity, as measured by android/gynoid fat ratio (A/G ratio), android/whole body fat proportion (A/W proportion), visceral (VAT) and subcutaneous fat (SAT) areas. Continuous metabolic syndrome score (cMetS), calculated as the sum of the age and sex-adjusted standardized residual (Z-score) of five established MetS components, was used to assess the MetS burden. Linear regression models were used to analyze the impact of DXA measures on cMetS and individual cMetS components. All models were adjusted for age, race, sex, and general obesity. Abdominal obesity is significantly associated with increased cMetS. With 1 standard deviation (SD) increase in A/G ratio, A/W proportion, VAT area, and SAT area, cMetS increased by 1.34 (SE=0.17), 1.25 (SE=0.19), 1.67 (SE=0.17), and 1.84 (SE=0.20) units, respectively. At individual component level, strongest association was observed between abdominal obesity and insulin resistance than lipid-based or blood pressure-based components. VAT and SAT had a stronger impact on insulin resistance than android ratio-based DXA measurements. Abdominal obesity is associated with higher MetS burden in adolescent population. The association between abdominal obesity and insulin resistance measure is the strongest, suggesting the key impact of abdominal obesity on insulin resistance in adolescents Mets burden.
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影响因子：
37.8
作者：
de Ferranti, SD;Gauvreau, K;Rifai, N
通讯作者：
Rifai, N
DOI：
10.1001/archpediatrics.2009.3
发表时间：
2009-04-01
影响因子：
--
作者：
Johnson, William D.;Kroon, Jolanda J. M.;Katzmarzyk, Peter T.
通讯作者：
Katzmarzyk, Peter T.
影响因子：
5.1
作者：
Morrison, John A.;Friedman, Lisa Aronson;Glueck, Charles J.
通讯作者：
Glueck, Charles J.
DOI：
10.1001/archpediatrics.2009.148
发表时间：
2009-09-01
影响因子：
--
作者：
Aucouturier, Julien;Meyer, Martine;Duche, Pascale
通讯作者：
Duche, Pascale
影响因子：
7.7
作者：
Gower, BA;Nagy, TR;Goran, MI
通讯作者：
Goran, MI