Dual-mode imaging and therapeutic effects of drug-loaded phase-transition nanoparticles combined with near-infrared laser and low-intensity ultrasound on ovarian cancer.
Dual-mode imaging and therapeutic effects of drug-loaded phase-transition nanoparticles combined with near-infrared laser and low-intensity ultrasound on ovarian cancer.
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载药相变纳米粒子联合近红外激光和低强度超声对卵巢癌的双模式成像及治疗效果
DOI：
10.1080/10717544.2018.1507062
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发表时间：
2018-11
期刊：
影响因子：
6
通讯作者：
Chang S
中科院分区：
文献类型：
--
作者：
Chen S;Liu Y;Zhu S;Chen C;Xie W;Xiao L;Zhu Y;Hao L;Wang Z;Sun J;Chang S
化疗与光声动力治疗（PSDT）可通过纳米给药平台联合使用，增强抗肿瘤疗效，但受肿瘤缺氧的限制，导致化疗耐药。全氟戊烷（PFP）具有携带氧气和汽化后增强超声或光声成像的能力。在此，我们构建了一种PFP核载氧，PLGA壳载吲哚菁绿（ICG）和紫杉醇（PTX）的PFP /ICG和载氧PLGA纳米粒子（PIO_NPs）。PIO_NPs具有良好的光学稳定性和过渡相能力。在近红外激光和低强度超声的作用下，能快速释放PTX并产生ROS。PIO_NPs增强了超声和PA成像的对比度。特别是，PIO_NPs可以用于监测和指导治疗，因为通过PA成像可以观察到PIO_NPs在肿瘤部位的积累。与PTX或其他纳米粒子相比，PIO_NPs联合激光和超声（L.U）可显著诱导SKOV3细胞凋亡，抑制SKOV3肿瘤生长。因此，PIO_NPs在肿瘤成像和治疗中具有很大的潜力。
Abstract Chemotherapy and photo-sonodynamic therapy (PSDT) can be combined through drug delivery nano-platforms to enhance the anti-tumor efficacy, however, which is limited by hypoxia in tumor, thereby causing chemotherapy resistance. Perfluoropentane (PFP) has the ability to carry oxygen and to enhance ultrasound or photoacoustic imaging after vaporization. Herein, we constructed a kind of nanoparticles (PTX/ICG and oxygen loaded PLGA nanoparticles (PIO_NPs)), which had PFP core carrying oxygen and PLGA shell loaded indocyanine green (ICG) and paclitaxel (PTX). PIO_NPs harbored good optical stability and the ability to transit phase. Moreover, it could rapidly release PTX and generate ROS under the mediation by near-infrared laser and low-intensity ultrasound. The PIO_NPs enhanced contrast of the ultrasound and PA imaging. In particular, PIO_NPs may be used to monitor and guide treatment for the accumulation of PIO_NPs at tumor site can be observed by PA imaging. Compared with PTX or other nanoparticles, PIO_NPs combined with laser and ultrasound (L.U) significantly induced apoptosis of SKOV3 cells and inhibited SKOV3 tumor growth. Therefore, PIO_NPs are of great potential in cancer imaging and therapy.
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近红外染料负载磁性纳米粒子作为增强肿瘤成像的光声造影剂
影响因子：
5.5
作者：
Gao C;Deng ZJ;Peng D;Jin YS;Ma Y;Li YY;Zhu YK;Xi JZ;Tian J;Dai ZF;Li CH;Liang XL
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Liang XL
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Liu Y;Nie L;Chen X
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Chen X
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作者：
Chen J;Liu C;Zeng G;You Y;Wang H;Gong X;Zheng R;Kim J;Kim C;Song L
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Song L
影响因子：
12.4
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Kim H;Kim Y;Kim IH;Kim K;Choi Y
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Choi Y
影响因子：
2.9
作者：
Li JH;Chen ZQ;Huang Z;Zhan Q;Ren FB;Liu JY;Yue W;Wang Z
通讯作者：
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