Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging.
Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging.
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近红外染料负载磁性纳米粒子作为增强肿瘤成像的光声造影剂
DOI：
10.20892/j.issn.2095-3941.2016.0048
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发表时间：
2016-09
影响因子：
5.5
通讯作者：
Liang XL
中科院分区：
文献类型：
--
作者：
Gao C;Deng ZJ;Peng D;Jin YS;Ma Y;Li YY;Zhu YK;Xi JZ;Tian J;Dai ZF;Li CH;Liang XL
目的：光声层析成像（PAT）由于其光吸收对比度和超声探测的优点而引起了人们的广泛兴趣。本研究旨在开发一种生物相容性和生物可降解的PA造影剂，特别是有希望在人体内的临床应用。研究方法：在本研究中，我们提出了一种PA造影剂：1，2-二硬脂酰-sn-甘油-3-磷酸乙醇胺- N-[甲氧基（聚乙二醇）]（DSPE-PEG）包被的超顺磁性氧化铁（SPIO）纳米颗粒（NPs）负载吲哚菁绿色（ICG）。我们使用ICG和SPIO NP，因为这两种药物都是美国食品和药物管理局批准的。考虑到近红外激光脉冲的强吸收，具有约28 nm的均匀直径的SPIO@DSPE-PEG/ICG NPs可以显著增强PA信号。结果如下：我们在体模和动物实验中证明了这些NPs的对比度增强，其中SPIO@DSPE-PEG/ICG NPs的体内循环时间比游离ICG长得多。这些新的纳米粒子也显示出高效率的肿瘤靶向。结论：SPIO@DSPE-PEG/ICG NPs是一种具有良好临床应用前景的PAT造影剂。
Objective: Photoacoustic (PA) tomography (PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human body. Methods: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[methoxy (polyethylene glycol)] (DSPE-PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles (NPs) loaded with indocyanine green (ICG). We used ICG and SPIO NPs because both drugs are approved by the U.S. Food and Drug Administration. Given the strong absorption of near-infrared laser pulses, SPIO@DSPE-PEG/ICG NPs with a uniform diameter of ~28 nm could significantly enhance PA signals. Results: We demonstrated the contrast enhancement of these NPs in phantom and animal experiments, in which the in vivo circulation time of SPIO@DSPE-PEG/ICG NPs was considerably longer than that of free ICG. These novel NPs also displayed a high efficiency of tumor targeting. Conclusions: SPIO@DSPE-PEG/ICG NPs are promising PAT contrast agents for clinical applications.
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影响因子：
3.8
作者：
Manohar, Srirang;Vaartjes, Susanne E.;van Leeuwen, Ton G.
通讯作者：
van Leeuwen, Ton G.
影响因子：
38.3
作者：
通讯作者：
--
影响因子：
15
作者：
Osaki, F;Kanamori, T;Aoyama, Y
通讯作者：
Aoyama, Y
早期肿瘤生长期间正在发育的脉管系统的无创光声成像
影响因子：
3.5
作者：
Lao, Yeqi;Xing, Da;Xiang, Liangzhong
通讯作者：
Xiang, Liangzhong
影响因子：
38.3
作者：
Jiang, Wen;Kim, Betty Y. S.;Chan, Warren C. W.
通讯作者：
Chan, Warren C. W.