Sleep apnea: relationship to age, sex, and Alzheimer's dementia.

Sleep apnea: relationship to age, sex, and Alzheimer's dementia.
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睡眠呼吸暂停:与年龄、性别和阿尔茨海默氏痴呆的关系。

DOI:
10.1093/sleep/6.1.16
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发表时间:
1983
期刊:
影响因子:
5.6
通讯作者:
Prinz,PN
Prinz,PN
中科院分区:
医学2区
文献类型:
--
作者:
Smallwood,RG;Vitiello,MV;Giblin,EC;Prinz,PN

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在45名老年受试者和10名年轻男性中研究了睡眠呼吸暂停与年龄、性别和阿尔茨海默氏症的关系,所有受试者均不肥胖、血压正常、不吸烟、无睡眠主诉,也无阿尔茨海默氏症以外的其他医疗问题。平均呼吸暂停/低通气指数[(AH)I]在老年男性中显著大于年轻男性或老年女性。在阿尔茨海默病组中,平均(AH)I和(AH)I > 5的受试者百分比与年龄和性别匹配的对照组没有显著差异。当用呼吸暂停指数代替(AH)I时,结果相似。这项初步研究的数据表明,健康的老年男性,没有睡眠投诉和老年男性与阿尔茨海默氏症的经验,在睡眠过程中显着的,亚临床症状的损害。10名老年女性和10名年轻男性的数据表明没有这种损害。这种程度的睡眠呼吸暂停在其他健康的老年男性中的生理意义目前尚不清楚。
The relationship of sleep apnea to age, sex, and Alzheimer's dementia was investigated in 45 elderly subjects and 10 young males, all nonobese, normotensive, nonsmoking, with no sleep complaints and no medical problems other than Alzheimer's disease. Mean apnea Jhypopnea index [(AH)I] was significantly greater in elderly males than in young males or elderly females. Mean (AH)I and percentage of subjects with an (AH)I > 5 in the Alzheimer groups were not significantly different from age and sex-matched controls. Results were similar when the apnea index was substituted for (AH)I. The data from this preliminary study indicate that healthy, elderly males with no sleep complaints and elderly males with Alzheimer's disease experience a significant, subclinical ventilatory impairment during sleep. Data from the 10 elderly females and 10 young males indicated no such impairment. The physiological significance of this degree of sleep apnea in otherwise healthy elderly males is unclear at present.
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