Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season.
Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season.
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DOI：
10.1016/j.vaccine.2014.06.052
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发表时间：
2015-01-01
期刊：
影响因子：
5.5
通讯作者：
VanWormer JJ
中科院分区：
文献类型：
--
作者：
Belongia EA;Sundaram ME;McClure DL;Meece JK;Ferdinands J;VanWormer JJ
最近的研究表明，疫苗诱导的对流感的保护可能会在一个季节内下降。我们重新分析了一项流感疫苗有效性研究的数据，以确定接种疫苗后的时间是否是甲型H3N1流感的独立预测因素。2007-2008年期间，积极招募了患有急性呼吸道疾病的患者。对呼吸道拭子进行流感检测，并通过有效的免疫登记确定疫苗接种日期。使用多变量Logistic回归分析流感RT-PCR结果与接种间隔(天数)之间的关系，并调整日历时间、年龄和其他混杂因素。共有629名接种疫苗的参与者，包括177例甲型H3N1流感病例和452名检测阴性的对照组。流感病例从接种疫苗到发病的平均间隔(SD)为101.7(25.9d)天，对照组为93.0d(29.9d)。在主效应模型中，接种间隔与流感结果显著相关。接种间隔每增加14天，调整后的流感优势比(AOR)为1.12(CI 1.01，1.26)。年龄改变了接种间隔和流感之间的联系(交互作用时p=0.005)。流感与幼儿和老年人的接种间隔增加有关，但与青少年或非老年人的接种间隔无关。当疫苗接种历周被评估为主要暴露变量时，也发现了类似的结果。甲型H3N2型流感的确诊与单一流感季节中幼儿和老年人接种疫苗以来时间的增加有关。
Recent studies have suggested that vaccine-induced protection against influenza may decline within one season. We reanalyzed data from a study of influenza vaccine effectiveness to determine if time since vaccination was an independent predictor of influenza A (H3N2). Patients with acute respiratory illness were actively recruited during the 2007–2008 season. Respiratory swabs were tested for influenza, and vaccination dates were determined by a validated immunization registry. The association between influenza RT-PCR result and vaccination interval (days) was examined using multivariable logistic regression, adjusting for calendar time, age and other confounders. There were 629 vaccinated participants, including 177 influenza A (H3N2) cases and 452 test negative controls. The mean (SD) interval from vaccination to illness onset was 101.7 (25.9) days for influenza cases and 93.0 (29.9) days for controls. There was a significant association between vaccination interval and influenza result in the main effects model. The adjusted odds ratio (aOR) for influenza was 1.12 (CI 1.01, 1.26) for every 14 day increase in the vaccination interval. Age modified the association between vaccination interval and influenza (p = 0.005 for interaction). Influenza was associated with increasing vaccination interval in young children and older adults, but not in adolescents or non-elderly adults. Similar results were found when calendar week of vaccine receipt was assessed as the primary exposure variable. Identification of influenza A (H3N2) was associated with increasing time since vaccination among young children and older adults during a single influenza season.
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DOI：
10.2217/1745509x.4.6.603
发表时间：
2008-12-01
期刊：
Aging health
影响因子：
--
作者：
McElhaney, Janet E
通讯作者：
McElhaney, Janet E
影响因子：
5.5
作者：
Irving, Stephanie A.;Donahue, James G.;Belongia, Edward A.
通讯作者：
Belongia, Edward A.
影响因子：
5.5
作者：
Belongia, Edward A.;Kieke, Burney A.;Shay, David K.
通讯作者：
Shay, David K.
影响因子：
6.4
作者：
Petrie, Joshua G.;Ohmit, Suzanne E.;Monto, Arnold S.
通讯作者：
Monto, Arnold S.
影响因子：
6.4
作者：
Skowronski, Danuta M.;Tweed, S. Aleina;De Serres, Gaston
通讯作者：
De Serres, Gaston