Computational Fluid Dynamics (CFD) Simulations of Spray Drying: Linking Drying Parameters with Experimental Aerosolization Performance.
Computational Fluid Dynamics (CFD) Simulations of Spray Drying: Linking Drying Parameters with Experimental Aerosolization Performance.
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DOI：
10.1007/s11095-020-02806-y
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发表时间：
2020-05-21
影响因子：
3.7
通讯作者：
Hindle M
中科院分区：
文献类型：
--
作者：
Longest PW;Farkas D;Hassan A;Hindle M
本研究的目的是开发一种新的计算流体动力学（CFD）为基础的模型，在实验室规模的喷雾干燥器内的复杂的运输和液滴干燥动力学，并与CFD预测的干燥参数从参考干粉吸入器（DPI）的粉末雾化度量。开发了Buchi Nano喷雾干燥器B-90的CFD模型，该模型捕获了来自先前实验研究的喷雾干燥器条件，该实验研究用L-亮氨酸作为分散增强剂生产赋形剂增强的生长粉末。计算流体力学模型占双向传热和传质耦合的阶段和湍流所产生的声流从网状雾化器。基于CFD的干燥参数在每个喷雾干燥器情况下对所有液滴进行平均，包括液滴时间平均干燥速率（κavg）、最大瞬时干燥速率（κmax）和沉淀窗口。计算流体动力学结果突出了混乱的干燥环境，其中每个喷雾干燥器情况下的时间平均液滴干燥速率（κavg）具有较高的变异性，变异系数在60- 70%的范围内。发现最大瞬时液滴干燥速率（κmax）比时间平均干燥速率高两个数量级。将CFD预测的干燥参数与实验确定的质量中位空气动力学直径（MMAD）和参考DPI的排放剂量（艾德）进行比较，产生了强线性相关性，决定系数高达R2=0.98。对于所考虑的喷雾干燥器系统和条件，当用参考DPI雾化粉末时，降低CFD预测的液滴经历的最大干燥速率改善了雾化性能（MMAD和艾德两者）。
The purpose of this study was to develop a new computational fluid dynamics (CFD)-based model of the complex transport and droplet drying kinetics within a laboratory-scale spray dryer, and relate CFD-predicted drying parameters to powder aerosolization metrics from a reference dry powder inhaler (DPI). A CFD model of the Buchi Nano Spray Dryer B-90 was developed that captured spray dryer conditions from a previous experimental study producing excipient enhanced growth powders with L-leucine as a dispersion enhancer. The CFD model accounted for two-way heat and mass transfer coupling between the phases and turbulent flow created by acoustic streaming from the mesh nebulizer. CFD-based drying parameters were averaged across all droplets in each spray dryer case and included droplet time-averaged drying rate (κavg), maximum instantaneous drying rate (κmax) and precipitation window. CFD results highlighted a chaotic drying environment in which time-averaged droplet drying rates (κavg) for each spray dryer case had high variability with coefficients of variation in the range of 60–70%. Maximum instantaneous droplet drying rates (κmax) were discovered that were two orders of magnitude above time-averaged drying rates. Comparing CFD-predicted drying parameters with experimentally determined mass median aerodynamic diameters (MMAD) and emitted doses (ED) from a reference DPI produced strong linear correlations with coefficients of determination as high as R2=0.98. For the spray dryer system and conditions considered, reducing the CFD-predicted maximum drying rate experienced by droplets improved the aerosolization performance (both MMAD and ED) when the powders were aerosolized with a reference DPI.
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DOI：
10.1089/jamp.2019.1540
发表时间：
2019-08-29
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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发表时间：
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影响因子：
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作者：
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影响因子：
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通讯作者：
Longest PW