Nitric oxide-dependent micro- and macrovascular dysfunction occurs early in adolescents with type 1 diabetes.
Nitric oxide-dependent micro- and macrovascular dysfunction occurs early in adolescents with type 1 diabetes.
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一氧化氮依赖性的微血管功能障碍发生在1型糖尿病的青少年早期。
DOI：
10.1152/ajpendo.00267.2021
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发表时间：
2022-02-01
期刊：
影响因子：
--
通讯作者：
Barrett EJ
中科院分区：
文献类型：
--
作者：
Jahn LA;Logan B;Love KM;Horton WB;Eichner NZ;Hartline LM;Weltman AL;Barrett EJ
1型糖尿病（DM 1）儿童的动脉僵硬度和内皮功能障碍均可预测未来的心血管事件。在健康的情况下，一氧化氮（NO）放松动脉，增加微血管灌注。在DM 1青少年中，NO依赖性大血管和微血管功能反应与动脉僵硬度之间的关系尚未研究。在这里，我们评估了DM 1青少年和年龄匹配的对照组在基线和口服葡萄糖挑战（OGTT）期间的大血管和微血管功能。DM 1青少年（n = 16）和对照组（n = 14）进行了研究之前和期间的OGTT。在基线时，我们测量：1）使用主动脉增强指数（AI）和颈动脉-股动脉脉搏波速度（cfPWV）的大动脉僵硬度; 2）使用缺血后血流速度（PIFV）的肱动脉血流介导的扩张（FMD）和前臂内皮功能; 3）使用超声造影的前臂肌肉微血管血容量（MBV）。OGTT后，AI，cfPWV和MBV在60分钟和MBV再次在120分钟进行重新评估。在个人和组间，比较进行配对和非配对t检验或重复测量方差分析。DM 1的基线FMD较低（P = 0.02）。0和60 min时的PWV在组间无差异。基线AI在组间无差异，但仅在对照组中随着OGTT下降（P = 0.02），并且在60 min时低于DM 1（P < 0.03）。DM 1组与对照组的基线MBV相当，但DM 1组在120 min时下降（P = 0.01），低于对照组（P < 0.03）。血糖与120 min MBV呈负相关（r =-0.523，P < 0.01）。两组间的最大吸氧量（mL/min/kg）、体脂（%）或体重指数（BMI）无差异。NO依赖性的大血管和微血管功能，包括FMD和AI，以及微血管灌注，分别在DM 1的早期过程中受损，先于动脉僵硬度的增加，并可能提供血管风险的早期指标。新&值得注意的是，这是第一项研究表明，1型糖尿病损害多种一氧化氮依赖性血管功能。
Arterial stiffness and endothelial dysfunction are both reported in children with type 1 diabetes (DM1) and may predict future cardiovascular events. In health, nitric oxide (NO) relaxes arteries and increases microvascular perfusion. The relationships between NO-dependent macro- and microvascular functional responses and arterial stiffness have not been studied in adolescents with DM1. Here, we assessed macro- and microvascular function in DM1 adolescents and age-matched controls at baseline and during an oral glucose challenge (OGTT). DM1 adolescents (n = 16) and controls (n = 14) were studied before and during an OGTT. At baseline, we measured: 1) large artery stiffness using both aortic augmentation index (AI) and carotid-femoral pulse wave velocity (cfPWV); 2) brachial flow-mediated dilation (FMD) and forearm endothelial function using postischemic flow velocity (PIFV); and 3) forearm muscle microvascular blood volume (MBV) using contrast-enhanced ultrasound. Following OGTT, AI, cfPWV, and MBV were reassessed at 60 min and MBV again at 120 min. Within individual and between-group, comparisons were made by paired and unpaired t tests or repeated measures ANOVA. Baseline FMD was lower (P = 0.02) in DM1. PWV at 0 and 60 min did not differ between groups. Baseline AI did not differ between groups but declined with OGTT only in controls (P = 0.02) and was lower than DM1 at 60 min (P < 0.03). Baseline MBV was comparable in DM1 and control groups, but declined in DM1 at 120 min (P = 0.01) and was lower than the control group (P < 0.03). There was an inverse correlation between plasma glucose and MBV at 120 min (r = –0.523, P < 0.01). No differences were noted between groups for V̇O2max (mL/min/kg), body fat (%), or body mass index (BMI). NO-dependent macro- and microvascular function, including FMD and AI, and microvascular perfusion, respectively, are impaired early in the course of DM1, precede increases of arterial stiffness, and may provide an early indicator of vascular risk. NEW & NOTEWORTHY This is the first study to show that type 1 diabetes impairs multiple nitric oxide-dependent vascular functions.
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影响因子：
3.8
作者：
Llaurado, Gemma;Simo, Rafael;Gonzalez-Clemente, Jose-Miguel
通讯作者：
Gonzalez-Clemente, Jose-Miguel
影响因子：
16.2
作者：
Ceriello A;Novials A;Ortega E;Canivell S;La Sala L;Pujadas G;Esposito K;Giugliano D;Genovese S
通讯作者：
Genovese S
DOI：
10.1161/atvbaha.107.153288
发表时间：
2007-12-01
影响因子：
8.7
作者：
Hamburg, Naomi M.;McMackin, Craig J.;Vita, Joseph A.
通讯作者：
Vita, Joseph A.
影响因子：
5.8
作者：
Liu, Jia;Jahn, Linda A.;Liu, Zhenqi
通讯作者：
Liu, Zhenqi
影响因子：
7.7
作者：
Coggins, M;Lindner, J;Barrett, E
通讯作者：
Barrett, E