Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) using Ultrasound Imaging with a Focus on Identifying Portal Hypertension.
Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) using Ultrasound Imaging with a Focus on Identifying Portal Hypertension.
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DOI：
10.3791/62050
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发表时间：
2020-12-05
期刊：
影响因子：
--
通讯作者：
Eisenbrey JR
中科院分区：
文献类型：
--
作者：
Forsberg F;Gupta I;Machado P;Shaw CM;Fenkel JM;Wallace K;Eisenbrey JR
长期以来，对人体内压力的无创、准确测量一直是一个重要但难以实现的临床目标。超声成像造影剂是一种充满气体的封装微泡（直径< 10 μm），可穿过整个血管系统并将信号增强高达30 dB。这些微泡还产生频率范围从次谐波（发射频率的一半）到高次谐波的非线性振荡。次谐波振幅与环境静水压力呈线性反比关系。在这里，提出了一种能够执行实时、分谐波辅助压力估计（SHAPE）的超声系统。在超声造影剂输注期间，激活用于优化声学输出的算法。在该校准之后，亚谐波微泡信号（即，SHAPE）对压力变化具有最高的灵敏度，可用于非侵入性地量化压力。SHAPE用于识别肝脏门静脉高压的实用性是这里的重点，但该技术在许多临床情况下都具有适用性。非侵入性的协议，估计环境压力，利用次谐波超声成像的注入造影剂微泡（以下适当的校准）的描述与人类慢性肝病患者的例子。
Noninvasive, accurate measurement of pressures within the human body has long been an important but elusive clinical goal. Contrast agents for ultrasound imaging are gas-filled, encapsulated microbubbles (diameter < 10 μm) that traverse the entire vasculature and enhance signals by up to 30 dB. These microbubbles also produce nonlinear oscillations at frequencies ranging from the subharmonic (half of the transmit frequency) to higher harmonics. The subharmonic amplitude has an inverse linear relationship with the ambient hydrostatic pressure. Here an ultrasound system capable of performing real-time, subharmonic aided pressure estimation (SHAPE) is presented. During ultrasound contrast agent infusion, an algorithm for optimizing acoustic outputs is activated. Following this calibration, subharmonic microbubble signals (i.e., SHAPE) have the highest sensitivity to pressure changes and can be used to noninvasively quantify pressure. The utility of the SHAPE procedure for identifying portal hypertension in the liver is the emphasis here, but the technique has applicability across many clinical scenarios. A protocol for noninvasively, estimating ambient pressures utilizing subharmonic ultrasound imaging of infused contrast microbubbles (following appropriate calibration) is described with examples from human patients with chronic liver disease.
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影响因子：
19.7
作者：
Gupta, Ipshita;Eisenbrey, John R.;Forsberg, Flemming
通讯作者：
Forsberg, Flemming
影响因子：
2.3
作者：
Halldorsdottir VG;Dave JK;Leodore LM;Eisenbrey JR;Park S;Hall AL;Thomenius K;Forsberg F
通讯作者：
Forsberg F
影响因子：
2.9
作者：
Shi, WT;Forsberg, F;Goldberg, BB
通讯作者：
Goldberg, BB
影响因子：
2.3
作者：
Eisenbrey, John R.;Daecher, Annemarie;Forsberg, Flemming
通讯作者：
Forsberg, Flemming
影响因子：
4.2
作者：
Forsberg, F;Shi, WT;Goldberg, BB
通讯作者：
Goldberg, BB