Characterization of Four Novel H5N6 Avian Influenza Viruses with the Internal Genes from H5N1 and H9N2 Viruses and Experimental Challenge of Chickens Vaccinated with Current Commercially Available H5 Vaccines.
Characterization of Four Novel H5N6 Avian Influenza Viruses with the Internal Genes from H5N1 and H9N2 Viruses and Experimental Challenge of Chickens Vaccinated with Current Commercially Available H5 Vaccines.
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具有 H5N1 和 H9N2 病毒内部基因的四种新型 H5N6 禽流感病毒的特征以及对接种当前市售 H5 疫苗的鸡的实验挑战。
DOI：
10.22541/au.160570812.29945789/v1
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发表时间：
2020-11
影响因子：
4.3
通讯作者：
Shijie Xie
中科院分区：
文献类型：
--
作者：
Peng Chen;Jinxiang Li;Jun Chu;Haiyuan Zhao;Lingxiang Xin;Guanlong Xu;wenbao Qi;Qiuchen Li;Xiaoyue Yang;Changdong Zhu;Yujie Li;Junda Zhu;Pengwei Zhao;Shijie Xie
自2014年以来，高致病性禽流感H5N6病毒一直是造成家禽暴发的原因。本研究从2019年山东省病白鸭和死鸡粪便中分离到4株H5N6病毒。这些H5N6病毒是三重重组病毒，以前未对其进行鉴定。它们的HA基因来源于H5病毒，与Re-11疫苗株密切相关。NA基因均属于n6样谱系，内部基因均来源于H5N1和H9N2病毒。它们都在小鼠中表现出高致病性，并在鸡中引起高传播率的致死性感染。此外，国内目前使用的H5 （Re-11和Re-12株）/H7 （H7- re -2株）三价灭活疫苗接种SPF鸡对这四种H5N6病毒具有完全的保护作用。本研究提示继续开展H5甲型流感病毒监测的必要性和及时更新疫苗毒株的重要性。
Since 2014, highly pathogenic avian influenza H5N6 viruses have been responsible for outbreaks in poultry. In this study, four H5N6 virus strains were isolated from fecal samples of sick white ducks and dead chickens in Shandong in 2019. These H5N6 viruses were triple-reassortant viruses that have not been previously characterized. Their HA genes were derived from the H5 viruses and were closely related to the vaccine strain Re-11. Their NA genes all fell into the N6-like lineage and the internal gene were derived from H5N1 and H9N2 viruses. They all showed high pathogenicity in mice and caused lethal infection with high rates of transmission in chickens. Moreover, the SPF chickens inoculated with the current used H5 (Re-11 and Re-12 strains)/H7 (H7-Re-2 strain) trivalent inactivated vaccines in China were completely protected from these four H5N6 viruses. Our study indicated the necessity of continued surveillance for H5 Influenza A viruses and the importance of timely update of vaccine strains in poultry industry.
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高度致病的禽流感附枝2.3.4.4 A（H5）病毒的大流行潜力。
影响因子：
11.1
作者：
Yamaji, Reina;Saad, Magdi D.;Davis, Charles T.;Swayne, David E.;Wang, Dayan;Wong, Frank Y. K.;McCauley, John W.;Peiris, J. S. Malik;Webby, Richard J.;Fouchier, Ron A. M.;Kawaoka, Yoshihiro;Zhang, Wenqing
通讯作者：
Zhang, Wenqing
影响因子：
6.7
作者：
Tong S;Zhu X;Li Y;Shi M;Zhang J;Bourgeois M;Yang H;Chen X;Recuenco S;Gomez J;Chen LM;Johnson A;Tao Y;Dreyfus C;Yu W;McBride R;Carney PJ;Gilbert AT;Chang J;Guo Z;Davis CT;Paulson JC;Stevens J;Rupprecht CE;Holmes EC;Wilson IA;Donis RO
通讯作者：
Donis RO
影响因子：
64.5
作者：
Linster M;van Boheemen S;de Graaf M;Schrauwen EJA;Lexmond P;Mänz B;Bestebroer TM;Baumann J;van Riel D;Rimmelzwaan GF;Osterhaus ADME;Matrosovich M;Fouchier RAM;Herfst S
通讯作者：
Herfst S
影响因子：
5.4
作者：
Guan, Y;Shortridge, KF;Peiris, M
通讯作者：
Peiris, M
DOI：
10.3390/v11111048
发表时间：
2019-11
期刊：
Viruses
影响因子：
--
作者：
Yafen Song;Weiqiang Li;Wenbo Wu;Zhiting Liu;Zhuoliang He;Zuxian Chen;Bingbing Zhao;Siyu Wu;Chenghuai Yang;Xiaoyun Qu;M. Liao;P. Jiao
通讯作者：
Yafen Song;Weiqiang Li;Wenbo Wu;Zhiting Liu;Zhuoliang He;Zuxian Chen;Bingbing Zhao;Siyu Wu;Chenghuai Yang;Xiaoyun Qu;M. Liao;P. Jiao