Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer.
Association between prediagnosis depression and mortality among postmenopausal women with colorectal cancer.
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DOI：
10.1371/journal.pone.0244728
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Luo J
中科院分区：
文献类型：
--
作者：
Liang X;Hendryx M;Qi L;Lane D;Luo J
目前还没有关于结直肠癌确诊前抑郁与结直肠癌患者，特别是绝经后女性结直肠癌死亡率之间关系的流行病学数据。我们的目标是填补这一研究空白。我们分析了来自美国一个大型预期队列的数据，妇女健康倡议(WHI)。这项研究包括1993-1998年间2396名患有结直肠癌的妇女，她们在癌症诊断前对抑郁症状和抗抑郁药的使用进行了基线评估(WHI研究中的筛查访问)。参与者接受了从癌症诊断到2018年的跟踪调查。我们使用COX比例风险回归来估计基线时抑郁(抑郁症状或抗抑郁药物的使用)与全因死亡率和结直肠癌特异性死亡率之间的调整风险比(HR)。在患有结直肠癌的女性中，在调整了年龄或多个协变量后，基线抑郁与全因死亡率或结直肠癌特异性死亡率之间没有相关性。在患有结直肠癌的女性中，结直肠癌确诊前的抑郁与全因死亡率或结直肠癌特有死亡率之间没有统计学意义的相关性。有必要进行进一步的研究，以评估抑郁症状和抗抑郁药物的使用，从基线到诊断的多点测量，以及它们与特定类型的结直肠癌治疗对结直肠癌死亡风险的相互作用。
There are no epidemiologic data on the relation of depression before colorectal cancer diagnosis to colorectal cancer mortality among women with colorectal cancer, especially those who are postmenopausal. Our aim was to fill this research gap. We analyzed data from a large prospective cohort in the US, the Women’s Health Initiative (WHI). The study included 2,396 women with incident colorectal cancer, assessed for depressive symptoms and antidepressant use before cancer diagnosis at baseline (screening visit in the WHI study) during 1993–1998. Participants were followed up from cancer diagnosis till 2018. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) between depression (depressive symptoms or antidepressant use) at baseline, and all-cause mortality and colorectal cancer-specific mortality. Among women with colorectal cancer, there was no association between baseline depression and all-cause mortality or colorectal cancer-specific mortality after adjusting for age or multiple covariates. Among women with colorectal cancer, there was no statistically significant association between depression before colorectal cancer diagnosis and all-cause mortality or colorectal cancer-specific mortality. Further studies are warranted to assess depressive symptoms and antidepressant use, measured at multiple points from baseline to diagnosis, and their interactions with specific types of colorectal cancer treatment on the risk of death from colorectal cancer.
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妇女健康计划观察性研究的65岁及65岁妇女的抗抑郁药，抑郁症状和事件脆弱。
影响因子：
6.3
作者：
Lakey SL;LaCroix AZ;Gray SL;Borson S;Williams CD;Calhoun D;Goveas JS;Smoller JW;Ockene JK;Masaki KH;Coday M;Rosal MC;Woods NF
通讯作者：
Woods NF
DOI：
10.1158/1055-9965.epi-17-1035
发表时间：
2018-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kiridly-Calderbank JF;Sturgeon SR;Kroenke CH;Reeves KW
通讯作者：
Reeves KW
影响因子：
3.3
作者：
Lutgendorf SK;Sood AK
通讯作者：
Sood AK
影响因子：
15.8
作者：
Murray CJ;Kulkarni SC;Michaud C;Tomijima N;Bulzacchelli MT;Iandiorio TJ;Ezzati M
通讯作者：
Ezzati M
影响因子：
6.2
作者：
Liang X;Margolis KL;Hendryx M;Reeves K;Wassertheil-Smoller S;Weitlauf J;Danhauer SC;Chlebowski RT;Caan B;Qi L;Lane D;Lavasani S;Luo J
通讯作者：
Luo J