Microbial endocrinology: Host-microbiota neuroendocrine interactions influencing brain and behavior.
Microbial endocrinology: Host-microbiota neuroendocrine interactions influencing brain and behavior.
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DOI：
10.4161/gmic.28682
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发表时间：
2014-05
期刊：
影响因子：
12.2
通讯作者：
Lyte M
中科院分区：
文献类型：
--
作者：
Lyte M
在过去的几年里，许多实验室已经证明了微生物的能力，无论是作为微生物区系中的共生生物还是作为治疗方案的一部分引入的微生物，都能够影响行为。然而，我们对微生物区系-肠道-大脑相互作用的机制缺乏了解。微生物区系的复杂性当然是一个促成因素。尽管如此，虽然微生物学家在研究行为中微生物区系-肠道-大脑相互作用的问题时很好地认识到了这种复杂性，但经常被忽视的是宿主神经生理系统的同样复杂性，特别是在肠道内，它由肠道神经系统以不同的方式支配。因此，在寻找微生物区系可以影响行为的共同机制时，可以寻找宿主和微生物区系共享的机制。这种跨界信号可以在真核生物和原核生物中发现的神经化学介质的共同产生中找到。研究神经化学物质的产生和识别，这些化学物质在结构上与脊椎动物产生的完全相同，被称为微生物内分泌学。从宿主-微生物区系神经内分泌相互作用的角度对微生物区系进行研究，不仅可以确定微生物区系可以影响宿主行为的基于微生物内分泌学的新机制，而且还可以导致干预措施的设计，其中微生物区系的组成可以被调节，以获得有利于整个宿主行为的基于微生物内分泌学的特定概况。
The ability of microorganisms, whether present as commensals within the microbiota or introduced as part of a therapeutic regimen, to influence behavior has been demonstrated by numerous laboratories over the last few years. Our understanding of the mechanisms that are responsible for microbiota-gut-brain interactions is, however, lacking. The complexity of the microbiota is, of course, a contributing factor. Nonetheless, while microbiologists approaching the issue of microbiota-gut-brain interactions in the behavior well recognize such complexity, what is often overlooked is the equal complexity of the host neurophysiological system, especially within the gut which is differentially innervated by the enteric nervous system. As such, in the search for common mechanisms by which the microbiota may influence behavior one may look for mechanisms which are shared by both host and microbiota. Such interkingdom signaling can be found in the shared production of neurochemical mediators that are found in both eukaryotes and prokaryotes. The study of the production and recognition of neurochemicals that are exactly the same in structure to those produced in the vertebrate organisms is known as microbial endocrinology. The examination of the microbiota from the vantage point of host-microbiota neuroendocrine interactions cannot only identify new microbial endocrinology-based mechanisms by which the microbiota can influence host behavior, but also lead to the design of interventions in which the composition of the microbiota may be modulated in order to achieve a specific microbial endocrinology-based profile beneficial to overall host behavior.
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影响因子：
4.1
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1016/b978-0-444-52002-9.00012-7
发表时间：
2012-01-01
期刊：
NEUROBIOLOGY OF PSYCHIATRIC DISORDERS
影响因子：
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作者：
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通讯作者：
Rothermundt, Matthias