Genetic variations in NF-κB were associated with the susceptibility to hepatitis C virus infection among Chinese high-risk population.
Genetic variations in NF-κB were associated with the susceptibility to hepatitis C virus infection among Chinese high-risk population.
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NF-κB基因变异与中国高危人群丙型肝炎病毒感染易感性相关
DOI：
10.1038/s41598-017-18463-y
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发表时间：
2018-01-08
影响因子：
4.6
通讯作者：
Yue M
中科院分区：
文献类型：
--
作者：
Tian T;Wang J;Huang P;Li J;Yu R;Fan H;Xia X;Han Y;Zhang Y;Yue M
NF-κB通路基因多态性可能与丙型肝炎病毒（HCV）感染易感性和结局相关。本研究旨在探讨NF-κB B基因单核苷酸多态性（SNP）与HCV感染易感性及消退的关系。采用TaqMan分析法对1125例未感染对照组、558例病毒自发清除组和898例HCV持续感染组的HCV基因组进行4种SNPs（rs 11820062、rs 230530、rs 1056890和rs3774963）的基因分型。Logistic回归分析表明，携带RelA rs 11820062 A等位基因的受试者患HCV的风险显著增加（P < 0.003125）。分层分析发现，rs 11820062 A等位基因对HCV易感性的增加在部分病例亚组中仍存在。本研究表明，NF-κB通路基因（rs 11820062 A等位基因）的遗传变异与中国高危人群中HCV易感性增加相关。
Polymorphisms within NF-κB pathway genes may be linked to hepatitis C virus (HCV) infection susceptibility and outcomes. We investigated the associations between single nucleotide polymorphisms (SNPs) in NF-κB and the susceptibility as well as resolution of HCV infection. A Chinese population, including 1125 uninfected control cases, 558 cases with spontaneous viral clearance and 898 cases with persistent HCV infection, was genotyped for four SNPs (rs11820062, rs230530, rs1056890 and rs3774963) using a TaqMan assay. Our logistic analyses indicate that the subjects carrying RelA rs11820062 A allele had a significantly increased risk of HCV susceptibility (P Bonferroni < 0.003125 in a dominant or additive model). In stratified analysis, the increased risk associated with rs11820062 A allele on HCV susceptibility remained in some case subgroups. This study demonstrates that a genetic variant involved in the NF-κB pathway gene (rs11820062 A allele) is associated with an increased HCV susceptibility within a high-risk Chinese population.
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DOI：
10.1038/nri2394
发表时间：
2008-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Fish EN
通讯作者：
Fish EN
影响因子：
6
作者：
Park MH;Hong JT
通讯作者：
Hong JT
影响因子：
14.2
作者：
Daley, Denise;Park, Julie E.;Sandford, Andrew J.
通讯作者：
Sandford, Andrew J.
GNPs-CS/KGM 作为具有抗生素作用的止血急救伤口敷料：体外和体内研究
影响因子：
3.7
作者：
Fan, Li;Cheng, Chong;Ren, Bo
通讯作者：
Ren, Bo
DOI：
10.1038/npp.2011.78
发表时间：
2011-08
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
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