Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory.
Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory.
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DOI：
10.1073/pnas.2123417119
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发表时间：
2022-11
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
过去十年，在识别支持认知的睡眠机制方面取得了重大进展。这些研究大多集中在睡眠期间中枢神经系统的电生理事件与不同认知领域的改善之间的联系，而自主神经系统在睡眠中的动态变化在很大程度上被忽视了。然而，最近的研究已经确定了睡眠期间自主神经输入对认知的重要贡献。然而，在理解中枢和自主神经系统如何在睡眠中协同工作以促进认知改善方面仍存在相当大的差距。在这篇文章中，我们研究了睡眠和清醒期间中枢和自主活动在认知加工中的独立和互动作用的证据。我们特别关注支持工作记忆的前额叶-皮层下结构和海马体依赖性情景记忆形成的机制。我们的慢振荡开关模型确定了在突触、系统和行为层面支持这两个记忆域的独立和竞争的潜在机制。我们提出，睡眠是一个竞争的竞技场，两个记忆领域争夺有限的资源，实验证明，当促进一个系统时，会导致电生理和行为结果的功能权衡。由于这些发现不可避免地会导致进一步的问题，我们建议未来的研究领域，以更好地了解大脑和身体如何相互作用，以支持单次睡眠期间广泛的认知领域。
The last decade has seen significant progress in identifying sleep mechanisms that support cognition. Most of these studies focus on the link between electrophysiological events of the central nervous system during sleep and improvements in different cognitive domains, while the dynamic shifts of the autonomic nervous system across sleep have been largely overlooked. Recent studies, however, have identified significant contributions of autonomic inputs during sleep to cognition. Yet, there remain considerable gaps in understanding how central and autonomic systems work together during sleep to facilitate cognitive improvement. In this article we examine the evidence for the independent and interactive roles of central and autonomic activities during sleep and wake in cognitive processing. We specifically focus on the prefrontal–subcortical structures supporting working memory and mechanisms underlying the formation of hippocampal-dependent episodic memory. Our Slow Oscillation Switch Model identifies separate and competing underlying mechanisms supporting the two memory domains at the synaptic, systems, and behavioral levels. We propose that sleep is a competitive arena in which both memory domains vie for limited resources, experimentally demonstrated when boosting one system leads to a functional trade-off in electrophysiological and behavioral outcomes. As these findings inevitably lead to further questions, we suggest areas of future research to better understand how the brain and body interact to support a wide range of cognitive domains during a single sleep episode.
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影响因子：
4.7
作者：
Breit S;Kupferberg A;Rogler G;Hasler G
通讯作者：
Hasler G
DOI：
10.1016/j.cub.2018.01.087
发表时间：
2018-03-19
期刊：
Current biology : CB
影响因子：
--
作者：
Cairney SA;Guttesen AÁV;El Marj N;Staresina BP
通讯作者：
Staresina BP
影响因子：
2.6
作者：
Ekstrom, Arne D.;Yonelinas, Andrew P.
通讯作者：
Yonelinas, Andrew P.
影响因子：
4.7
作者：
Brandenberger, G;Ehrhart, J;Simon, C
通讯作者：
Simon, C
影响因子：
16.2
作者：
Chauvette S;Seigneur J;Timofeev I
通讯作者：
Timofeev I