GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation.
GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation.
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DOI：
10.1038/s41598-021-02157-7
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发表时间：
2021-11-22
影响因子：
4.6
通讯作者：
Clem RL
中科院分区：
文献类型：
--
作者：
Roman-Ortiz C;Guevara JA;Clem RL
Behaviors central to the procurement and consumption of food are among those most fundamental to survival, but their inappropriate expression can lead to overeating and obesity. Nevertheless, we have a poor understanding of circuits that promote feeding independent of physiological demand. Here we demonstrate that activation of basal forebrain (BF) GABAergic neurons results in consumption of food as well as non-food items in well-fed mice, and performance of fictive eating in the absence of ingestible materials. In addition, stimulation of these cells disrupts defensive threat responses and elicits reward-like motivational effects. Finally, BF GABAergic activity triggers skilled predatory attacks of live prey and prey-like objects, but not social targets. These effects were entirely recapitulated by selective stimulation of BF GABAergic projections to the periaqueductal gray (PAG). Our results outline a potent circuit mechanism for increased feeding through recruitment of distinct but synergistic behaviors, and add to growing evidence that PAG is an important integrator of feeding-related activity.
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DOI：
10.1007/7854_2016_467
发表时间：
2018-01-01
期刊：
BEHAVIORAL NEUROSCIENCE OF LEARNING AND MEMORY
影响因子：
--
作者：
Blake, M. G.;Boccia, M. M.
通讯作者：
Boccia, M. M.
影响因子：
2.7
作者：
Comoli, E;Ribeiro-Barbosa, ER;Canteras, NS
通讯作者：
Canteras, NS
基底前脑 GABA 能神经元促进唤醒和掠夺性狩猎
影响因子：
4.7
作者：
Cai, Ping;Chen, Li;Yu, Chang-Xi
通讯作者：
Yu, Chang-Xi
食物的感官检测快速调节弧形喂食电路。
影响因子：
64.5
作者：
Chen Y;Lin YC;Kuo TW;Knight ZA
通讯作者：
Knight ZA
影响因子：
15.9
作者：
Pellman BA;Kim JJ
通讯作者：
Kim JJ