Association between childhood adversity and a diagnosis of personality disorder in young adulthood: a cohort study of 107,287 individuals in Stockholm County.
Association between childhood adversity and a diagnosis of personality disorder in young adulthood: a cohort study of 107,287 individuals in Stockholm County.
复制标题
DOI：
10.1007/s10654-017-0264-9
复制
发表时间：
2017-08
影响因子：
13.6
通讯作者：
Björkenstam C
中科院分区：
文献类型：
--
作者：
Björkenstam E;Ekselius L;Burström B;Kosidou K;Björkenstam C
童年期的逆境可能增加日后发展为人格障碍的风险。然而，对累积CA和PD之间的关联，以及儿童精神病理学和学校表现的作用知之甚少。目前的研究探讨了一系列CA和PD的诊断在年轻的成年人之间的关系，以及儿童精神病理学和学校表现在这种关系中的作用。1987-1991年出生于斯德哥尔摩县的所有个体（n = 107，287）构成了我们的队列。七CA测量出生和14岁之间：家庭死亡，父母犯罪，父母药物滥用和精神病发病率，父母分居和/或单亲家庭，家庭公共援助和住宅不稳定。个体从18岁生日起接受随访，直至被诊断为PD或随访结束（2011年12月31日）。PD风险的校正估计值计算为风险比（HR）和95%置信区间（CI）。观察到累积CA和PD之间的关联。在随访期间，770人（0.7%）被诊断为PD。暴露于3+ CA的个体被诊断为PD的风险最高（HR 3.0，95% CI 2.4-3.7）。儿童期精神病理学和低学校成绩进一步增加了暴露于CA的个体中PD的风险。累积性CA与年轻人PD的诊断密切相关。我们的研究结果表明，学校和卫生服务部门应特别关注面临逆境的儿童，以防止学业成绩下降，并发现可能处于负面人生轨迹的弱势个体。本文的在线版本（doi：10.1007/s10654-017-0264-9）包含补充材料，可供授权用户使用。
Childhood adversity (CA) may increase the risk for later developing of personality disorder (PD). However, less is known about the association between cumulative CA and PD, and the role of childhood psychopathology and school performance. The current study examined the relationship between a range of CAs and a diagnosis of PD in young adulthood, and the roles of childhood psychopathology and school performance in this relationship. All individuals born in Stockholm County 1987–1991 (n = 107,287) constituted our cohort. Seven CAs were measured between birth and age 14: familial death, parental criminality, parental substance abuse and psychiatric morbidity, parental separation and/or single-parent household, household public assistance and residential instability. Individuals were followed from their 18th birthday until they were diagnosed with PD or until end of follow-up (December 31st 2011). Adjusted estimates of risk of PD were calculated as hazard ratios (HR) with 95% confidence intervals (CI). Associations were observed between cumulative CA and PD. During the follow-up 770 individuals (0.7%) were diagnosed with PD. Individuals exposed to 3+ CAs had the highest risks of being diagnosed with PD (HR 3.0, 95% CI 2.4–3.7). Childhood psychopathology and low school grades further increased the risk of PD among individuals exposed to CA. Cumulative CA is strongly associated with a diagnosis of PD in young adulthood. Our findings indicate that special attention should be given in schools and health services to children exposed to adversities to prevent decline in school performance, and to detect vulnerable individuals that may be on negative life-course trajectories. The online version of this article (doi:10.1007/s10654-017-0264-9) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
10.5
作者：
Bjorkenstam, Emma;Bjorkenstam, Charlotte;Ekselius, Lisa
通讯作者：
Ekselius, Lisa
DOI：
10.1192/bjp.bp.108.058552
发表时间：
2009-07
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Huang Y;Kotov R;de Girolamo G;Preti A;Angermeyer M;Benjet C;Demyttenaere K;de Graaf R;Gureje O;Karam AN;Lee S;Lépine JP;Matschinger H;Posada-Villa J;Suliman S;Vilagut G;Kessler RC
通讯作者：
Kessler RC
影响因子：
6.3
作者：
Bjorkenstam, Emma;Dalman, Christina;Burstrom, Bo
通讯作者：
Burstrom, Bo
影响因子：
4.4
作者：
Gravseth, Hans Magne;Bjerkedal, Tor;Kristensen, Petter
通讯作者：
Kristensen, Petter
影响因子：
2.3
作者：
Cohen, P;Crawford, TN;Kasen, S
通讯作者：
Kasen, S