Differentiation of Hebbian and homeostatic plasticity mechanisms within layer 5 visual cortex neurons.
Differentiation of Hebbian and homeostatic plasticity mechanisms within layer 5 visual cortex neurons.
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DOI：
10.1016/j.celrep.2022.110892
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发表时间：
2022-05-31
期刊：
影响因子：
8.8
通讯作者：
Fox, Kevin
中科院分区：
文献类型：
--
作者：
Pandey, Anurag;Hardingham, Neil;Fox, Kevin
皮质层 5 包含两种主要类型的投射神经元，称为在皮质下投射的 IB（内在爆发）细胞和在皮质区域之间投射的 RS（规则尖峰）细胞。本研究描述了小鼠视觉皮层中RS和IB细胞在眼优势可塑性关键时期的可塑性特性。我们发现 RS 神经元在对暗暴露 (DE) 和单眼剥夺 (MD) 的反应中表现出突触抑制，并且它们从抑制中恢复的稳态恢复依赖于 TNF-α。相反，IB细胞对DE和MD表现出相反的反应，增强DE并抑制MD。 IB 细胞的增强取决于 CaMKII 自磷酸化，而不是 TNF-α。 IB细胞在关键期开始时表现出成熟的突触特性，而RS细胞在关键期期间成熟。结合体感皮层的观察结果，这些结果表明 RS 和 IB 可塑性机制的差异是一种普遍的皮层特性。第 5 层 RS 细胞突触在眼优势可塑性的关键时期成熟 第 5 层 RS 但不是 IB 细胞显示出 TNF-α 依赖性的从抑郁状态恢复的稳态恢复 第 5 层 IB 但不是 RS 细胞显示出 CaMKII-自磷酸化依赖性增强 在 IB 细胞中，棘头大小的增加先于功能增强 Pandey 等人。研究表明，视觉皮层中投射到不同神经元目标的细胞表现出不同的突触可塑性机制。虽然常规尖峰 (RS) 细胞表现出突触抑制，并表现出 TNF-α 依赖性的稳态恢复，但内在爆发 (IB) 细胞显示出依赖于 CaMKII 自磷酸化而不是 TNF-α 的增强作用。
Cortical layer 5 contains two major types of projection neuron known as IB (intrinsic bursting) cells that project sub-cortically and RS (regular spiking) cells that project between cortical areas. This study describes the plasticity properties of RS and IB cells in the mouse visual cortex during the critical period for ocular dominance plasticity. We find that RS neurons exhibit synaptic depression in response to both dark exposure (DE) and monocular deprivation (MD), and their homeostatic recovery from depression is dependent on TNF-α. In contrast, IB cells demonstrate opposite responses to DE and MD, potentiating to DE and depressing to MD. IB cells’ potentiation depends on CaMKII-autophosphorylation and not TNF-α. IB cells show mature synaptic properties at the start of the critical period while RS cells mature during the critical period. Together with observations in somatosensory cortex, these results suggest that differences in RS and IB plasticity mechanisms are a general cortical property. Layer 5 RS cell synapses mature during critical period for ocular dominance plasticity Layer 5 RS but not IB cells show TNF-α-dependent homeostatic recovery from depression Layer 5 IB but not RS cells show CaMKII-autophosphorylation-dependent potentiation Increases in spine head size precede functional potentiation in IB cells Pandey et al. show that cells in the visual cortex projecting to different neuronal targets exhibit different synaptic plasticity mechanisms. While regular spiking (RS) cells show synaptic depression and exhibit TNF-α-dependent homeostatic recovery from depression, intrinsic bursting (IB) cells show potentiation that depends on CaMKII-autophosphorylation and not TNF-α.
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影响因子：
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影响因子：
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CAMKII自磷酸化对于在LTP诱导期间的CA（2+）信号的最佳整合是必需的，但不是维护。
影响因子：
16.2
作者：
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