The stability and persistence of symptoms in childhood-onset ADHD.
The stability and persistence of symptoms in childhood-onset ADHD.
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儿童期多动症症状的稳定性和持续性。
DOI：
10.1007/s00787-023-02235-3
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发表时间：
2024
影响因子：
6.4
通讯作者：
Arnold,LEugene
中科院分区：
文献类型：
--
作者：
VanMeter,AnnaR;Sibley,MargaretH;Vandana,Pankhuree;Birmaher,Boris;Fristad,MaryA;Horwitz,Sarah;Youngstrom,EricA;Findling,RobertL;Arnold,LEugene
儿童期发病的注意缺陷多动障碍（ADHD）的病程因人而异；有些人会经历持续的症状，而另一些人的症状会波动或缓解。我们描述了ADHD症状的纵向过程和相关的临床特征在青少年儿童期发病ADHD。来自躁狂症状纵向评估（LAMS）研究的参与者（基线年龄6-12岁）在12岁之前符合ADHD的DSM标准，每年使用儿童情感障碍和精神分裂症时间表进行评估，为期8年。在每个时间点，参与者被分类为符合ADHD标准、亚阈值标准或没有ADHD。病程的稳定性是由参与者是否经历了持续的ADHD症状、波动的症状或缓解来定义的。症状的持续以最后两次随访时的症状状态来定义（稳定的ADHD，稳定的缓解，稳定的部分缓解，不稳定）。在685名基线参与者中，431名患有儿童期ADHD，并至少进行了两次随访。一半的人有持续的ADHD病程，近40%的人有缓解的病程，其余的人有波动的病程。超过一半的参与者在参与结束时符合ADHD的标准；约30%表现为稳定的完全缓解，15%表现为不稳定症状，1例表现为稳定的部分缓解。病程持续且结果稳定的ADHD参与者报告的症状数量最多，受损程度也最大。这项工作建立在早期研究的基础上，这些研究描述了患有儿童多动症的年轻人的波动症状。结果强调了持续监测和详细评估可能影响过程和结果的因素对帮助患有儿童期ADHD的年轻人的重要性。
The course of childhood-onset attention deficit hyperactivity disorder (ADHD) varies across individuals; some will experience persistent symptoms while others’ symptoms fluctuate or remit. We describe the longitudinal course of ADHD symptoms and associated clinical characteristics in adolescents with childhood-onset ADHD. Participants (aged 6–12 at baseline) from the Longitudinal Assessment of Manic Symptoms (LAMS) study who met DSM criteria for ADHD prior to age 12 were evaluated annually with the Kiddie Schedule for Affective Disorders and Schizophrenia for eight years. At each timepoint, participants were categorized as meeting ADHD criteria, subthreshold criteria, or not having ADHD. Stability of course was defined by whether participants experienced consistent ADHD symptoms, fluctuating symptoms, or remission. The persistence of the symptoms was defined by symptom status at the final two follow-ups (stable ADHD, stable remission, stable partial remission, unstable). Of 685 baseline participants, 431 had childhood-onset ADHD and at least two follow-ups. Half had a consistent course of ADHD, nearly 40% had a remitting course, and the remaining participants had a fluctuating course. More than half of participants met criteria for ADHD at the end of their participation; about 30% demonstrated stable full remission, 15% had unstable symptoms, and one had stable partial remission. Participants with a persistent course and stable ADHD outcome reported the highest number of symptoms and were most impaired. This work builds on earlier studies that describe fluctuating symptoms in young people with childhood-onset ADHD. Results emphasize the importance of ongoing monitoring and detailed assessment of factors likely to influence course and outcome to help young people with childhood-onset ADHD.
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影响因子：
4.8
作者：
Biederman J;Petty CR;Clarke A;Lomedico A;Faraone SV
通讯作者：
Faraone SV
DOI：
10.1097/00004583-200104000-00014
发表时间：
2001-04-01
影响因子：
13.3
作者：
Geller, B;Zimerman, B;Soutullo, C
通讯作者：
Soutullo, C
影响因子：
17.7
作者：
Kessler, RC;Adler, L;Zaslavsky, AM
通讯作者：
Zaslavsky, AM
影响因子：
7.7
作者：
Polanczyk, Guilherme V.;GWillcutt, Erik;Rohde, Luis A.
通讯作者：
Rohde, Luis A.
哌醋甲酯、心理社会治疗及其组合对学龄多动症儿童的疗效：一项荟萃分析。
影响因子：
12.8
作者：
S. Oord;P. Prins;J. Oosterlaan;P. Emmelkamp
通讯作者：
P. Emmelkamp