Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods.
Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods.
复制标题
金纳米棒表面分子密度调节癌细胞的死亡途径
DOI：
10.1002/advs.202102666
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Zhang F;Hou Y;Zhu M;Deng B;Zhao M;Zhu X;Sun Y;Chen D;Jiang C;Wang L;Chen C;Chen H;Chen H;Zheng H;Li W
与细胞凋亡相比，坏死诱导强烈的炎症，在临床上具有不良影响。幸运的是，坏死和细胞凋亡之间的切换可以通过调整金纳米棒（GNR）的适当结构特性来实现，从而精确调节细胞死亡途径。在此，GNRs和细胞器之间的细胞内相互作用进行监测，发现溶酶体主导坏死/凋亡诱发。然后计算GNRs的表面分子密度，首先定义为ρsurf。分子（Nsurf.分子/（a × π ×直径×长度）），介导溶酶体活性，如膜透化（LMP）、组织蛋白酶B和D的释放、溶酶体与不同细胞器之间的相互作用，选择性地诱导巨噬细胞凋亡或坏死以及TNF-α的产生。具有小ρsurf的GNR。分子主要诱导细胞凋亡，而ρsurf较大。分子，它们极大地促进了坏死。有趣的是，具有较高ρsurf的GNR可以抑制坏死。由于关键蛋白酶半胱天冬酶8的过表达，其切割RIP 1-RIP 3复合物并激活半胱天冬酶3，随后由坏死向凋亡转变，导致了这种分子。研究表明，ρ冲浪.纳米材料的分子结构对纳米材料的应用有很大的影响，不同的纳米材料的结构特性对临床应用有不同的意义。
Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis could be realized by tailoring the appropriate structural properties of gold nano rods (GNRs) that could precisely modulate cell death pathways. Herein, the intracellular interaction between GNRs and organelles is monitored and it is found that lysosomes dominates necrosis/apoptosis evoking. Then the surface molecule density of GNRs, which is first defined as ρsurf. molecule (Nsurf. molecules/(a × π × Diameter × Length)), mediates lysosome activities as the membrane permeabilization (LMP), the Cathepsin B and D release, the cross‐talk between lysosome and different organelles, which selectively evokes apoptosis or necrosis and the production of TNF‐α from macrophages. GNRs with small ρsurf. molecule mainly induce apoptosis, while with large ρsurf. molecule they greatly contribute to necrosis. Interestingly, necrosis can be suppressed by GNRs with higher ρsurf. molecule due to the overexpression of key protease caspase 8, which cleaves the RIP1‐RIP3 complex and activates caspase 3 followed by necrosis to apoptosis transition. This investigation indicates that the ρsurf. molecule greatly affects the utility of nanomaterials and different structural properties of nanomaterials have different implications in clinics.
登录
查看更多内容
影响因子：
10.8
作者：
Durr, Nicholas J.;Larson, Timothy;Ben-Yakar, Adela
通讯作者：
Ben-Yakar, Adela
影响因子：
10.5
作者：
Lin, Y;Devin, A;Liu, ZG
通讯作者：
Liu, ZG
通过精细定制抗 Her2 锚定双靶向免疫胶束进行胃癌化疗。
影响因子：
14
作者：
Li, Wei;Zhao, He;Guo, Yajun
通讯作者：
Guo, Yajun
影响因子：
10.8
作者：
Chen, Jingyi;Wang, Danling;Li, Xingde
通讯作者：
Li, Xingde
影响因子：
4.6
作者：
Li, Wei;Nakayama, Masamichi;Okano, Teruo
通讯作者：
Okano, Teruo