Obesity and Bone Health: A Complex Link.
Obesity and Bone Health: A Complex Link.
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肥胖与骨骼健康：复杂的联系
DOI：
10.3389/fcell.2020.600181
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发表时间：
2020
影响因子：
5.5
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Hou J;He C;He W;Yang M;Luo X;Li C
到目前为止，肥胖和骨骼之间的联系已经被广泛探索，但结果并不一致。肥胖通过多种机制影响骨健康，包括体重、脂肪体积、骨形成/吸收、促炎细胞因子以及骨髓微环境。本文主要介绍白色脂肪组织分泌的脂肪因子对骨细胞的影响，以及棕色脂肪组织、骨髓脂肪组织与骨代谢的相互作用。同时，本文还综述了脂肪组织及其分布对骨量和骨相关疾病的影响的证据，沿着不同人群肥胖与骨健康的相关性。我们描述了神经性厌食症或2型糖尿病患者骨代谢的变化。总之，所有这些研究结果表明，骨骼对肥胖的反应是复杂的，并取决于多种因素，如机械负荷，肥胖类型，脂肪组织的位置，性别，年龄，骨骼部位和分泌的细胞因子，这些因素可能在骨骼健康中发挥主要作用。
So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone marrow microenvironment. In this review, we will mainly describe the effects of adipokines secreted by white adipose tissue on bone cells, as well as the interaction between brown adipose tissue, bone marrow adipose tissue, and bone metabolism. Meanwhile, this review also reviews the evidence for the effects of adipose tissue and its distribution on bone mass and bone-related diseases, along with the correlation between different populations with obesity and bone health. And we describe changes in bone metabolism in patients with anorexia nervosa or type 2 diabetes. In summary, all of these findings show that the response of skeleton to obesity is complex and depends on diversified factors, such as mechanical loading, obesity type, the location of adipose tissue, gender, age, bone sites, and secreted cytokines, and that these factors may exert a primary function in bone health.
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DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
DOI：
10.1093/gerona/glz149
发表时间：
2020-01-01
影响因子：
5.1
作者：
Al Saedi, Ahmed;Goodman, Craig A.;Duque, Gustavo
通讯作者：
Duque, Gustavo
影响因子：
1.9
作者：
Alissa, Eman M.;Alzughaibi, Layla S.;Marzouki, Zuhair M.
通讯作者：
Marzouki, Zuhair M.
影响因子：
3.7
作者：
Brown, JL;Spicer, MT;Spicer, LJ
通讯作者：
Spicer, LJ
影响因子：
4
作者：
Astudillo, Pablo;Rios, Susana;Rodriguez, J. Pablo
通讯作者：
Rodriguez, J. Pablo