Regulation of adult neurogenesis by behavior and age in the accessory olfactory bulb.
Regulation of adult neurogenesis by behavior and age in the accessory olfactory bulb.
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DOI：
10.1016/j.mcn.2011.05.003
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发表时间：
2011-08
影响因子：
3.5
通讯作者：
Araneda, Ricardo C.
中科院分区：
文献类型：
--
作者：
Nunez-Parra, Alexia;Pugh, Victoria;Araneda, Ricardo C.
犁鼻系统（vomeronasal system，VNS）参与与社会和性行为相关的信息素信息的检测和处理。在VNS内，两个不同的感觉神经元群体，具有不同的分布模式，衬犁鼻器（VNO）的上皮细胞，并产生分离的感觉投射到副嗅球（AOB）。VNO中的顶端感觉神经元投射到前AOB（aAOB），而基底神经元投射到后AOB（pAOB）。在AOB中，最大的神经元群体是抑制性的颗粒细胞和肾小球周围细胞（GC和PG），并且值得注意的是，这些神经元在成人脑中连续出生并在功能上整合，强调了它们在嗅觉功能中的作用。在这里，我们表明，行为介导的VNS差异调节成人神经发生的前-后轴的AOB。我们使用免疫组织化学标记的新生细胞在不同的行为条件下的小鼠。使用居民入侵者的侵略范例，我们发现，下属小鼠表现出增加的aAOB神经发生。此外，在性幼稚的成年女性暴露于肮脏的床上用品气味的成年男性，新出生的细胞的数量显着增加的pAOB，然而，神经发生不受影响的女性暴露于女性的气味。此外，我们发现，在两个月大的成年神经发生是性二态的，雄性小鼠表现出比雌性小鼠更高水平的新生细胞。有趣的是，成年神经发生随着年龄的增长而大大减少，这种减少与祖细胞增殖的减少有关，但与AOB中细胞死亡的增加无关。这些结果表明，成人的AOB神经发生的生理调节行为是性别和年龄依赖性的，并建议在VNS介导的性别依赖性行为的重要作用，新生神经元。
The vomeronasal system (VNS) participates in the detection and processing of pheromonal information related to social and sexual behaviors. Within the VNS, two different populations of sensory neurons, with a distinct pattern of distribution, line the epithelium of the vomeronasal organ (VNO) and give rise to segregated sensory projections to the accessory olfactory bulb (AOB). Apical sensory neurons in the VNO project to the anterior AOB (aAOB), while basal neurons project to the posterior AOB (pAOB). In the AOB, the largest population of neurons are inhibitory, the granule and periglomerular cells (GCs and PGs) and remarkably, these neurons are continuously born and functionally integrated in the adult brain, underscoring their role on olfactory function. Here we show that behaviors mediated by the VNS differentially regulate adult neurogenesis across the anterior-posterior axis of the AOB. We used immunohistochemical labeling of newly born cells under different behavioral conditions in mice. Using a resident-intruder aggression paradigm, we found that subordinate mice exhibited increased neurogenesis in the aAOB. In addition, in sexually naive adult females exposed to soiled bedding odorized by adult males, the number of newly born cells was significantly increased in the pAOB; however, neurogenesis was not affected in females exposed to female odors. In addition, we found that at two months of age adult neurogenesis was sexually dimorphic, with male mice exhibiting higher levels of newly born cells than females. Interestingly, adult neurogenesis was greatly reduced with age and this decrease correlated with a decrease in progenitor cells proliferation but not with an increase in cell death in the AOB. These results indicate that the physiological regulation of adult neurogenesis in the AOB by behaviors is both sex and age dependent and suggests an important role of newly born neurons in sex dependent behaviors mediated by the VNS.
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影响因子：
64.5
作者：
Herrada, G;Dulac, C
通讯作者：
Dulac, C
影响因子：
3.5
作者：
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Swann, JM
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作者：
Chamero, Pablo;Marton, Tobias F.;Stowers, Lisa
通讯作者：
Stowers, Lisa
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作者：
Heinrichs, Stephen C;Koob, George F
通讯作者：
Koob, George F
影响因子：
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作者：
Enwere, E;Shingo, T;Weiss, S
通讯作者：
Weiss, S